Results 111 to 120 of about 148,918 (213)

Current understanding of the NLRC4 Inflammasome in autoinflammation and enterocolitis

Communications Biology
The NLRC4 inflammasome is a cytosolic immune sensor that detects bacterial virulence structures and rapidly initiates inflammatory responses. While tightly regulated NLRC4 activation is essential for host defense, genetic mutations that enhance NLRC4 ...
Yuhang Wang, Sivakumar Lingappa, Zizhen Kang   +2 more
doaj   +1 more source

Autoinflammatory disease: clinical perspectives and therapeutic strategies. [PDF]

Inflamm Regen, 2022
Kawakami A, Endo Y, Koga T, Yoshiura KI, Migita K.   +4 more
europepmc   +1 more source

Beyond Venous Inflammation: Vessel Wall Imaging of Intracranial Arteries in Neuro‐Behçet's Syndrome

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Background Neuro‐Behçet syndrome (NBS) is a heterogeneous inflammatory disorder in which venous involvement is well recognized, while intracranial arterial pathology remains insufficiently characterized. Conventional luminal imaging methods are limited in detecting early or isolated arterial wall abnormalities.
Esra Kochan Kizilkilic, Bora Korkmazer, Nursena Erener, Ahmet Kursat Karaman, Abdullah Arcan, Serdar Arslan, Aksel Siva, Emire Seyahi, Ugur Uygunoglu, Osman Kizilkilic   +9 more
wiley   +1 more source

Correction: Autoinflammatory disease: clinical perspectives and therapeutic strategies. [PDF]

Inflamm Regen, 2022
Kawakami A, Endo Y, Koga T, Yoshiura KI, Migita K.   +4 more
europepmc   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT In vertebrate adaptive immune systems, somatically diversified antigen receptors assume a central role in self/nonself discrimination. Attesting to the presence of a unique but unknown selective environment at early stages of vertebrate evolution, this facility emerged twice, in the ancestors of jawless and jawed vertebrates.
Thomas Boehm, Orlando B. Giorgetti
wiley   +1 more source

VEXAS syndrome: an adult-onset monogenic autoinflammatory disease with many unanswered questions. [PDF]

Reumatologia, 2023
Hernández-Rodríguez J, Nieścieruk J, Maślińska M.   +2 more
europepmc   +1 more source

Candida oesophagitis as an Initial Manifestation of VEXAS Syndrome: Expanding Evidence for an Acquired Immunodeficiency Phenotype

eJHaem, Volume 7, Issue 4, August 2026.
Demi Rianne Vintges, Marina Weerheim, Faiz Karim   +2 more
wiley   +1 more source

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 8, Page 1318-1331, August 2026.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

A unique presentation of NLRP3-associated autoinflammatory disease: case report. [PDF]

BMC Rheumatol, 2022
Ducharme-Bénard S, Roberge G, Chapdelaine H.   +2 more
europepmc   +1 more source