Results 111 to 120 of about 168,848 (280)

Long‐term echocardiographic findings in patients with idiopathic recurrent pericarditis treated with anakinra

Internal Medicine Journal, EarlyView.
Abstract Aim Idiopathic recurrent pericarditis (IRP) is considered an autoinflammatory disease, and interleukin 1 inhibitors, such as anakinra, are used to treat resistant cases. Constrictive pericarditis, a feared complication, continues to be a critical concern. In the biologic era, evidence on long‐term transthoracic echocardiographic (TTE) findings
Zeynep Toker Dincer, Damla Raimoglou, Erkin Yilmaz, Ayten Dag, Melike Melikoglu, Serdal Ugurlu   +5 more
wiley   +1 more source

NOD2 and inflammation: current insights [PDF]

, 2018
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Cucchiara, Salvatore, Negroni, Anna, Pierdomenico, Maria, Stronati, Laura   +3 more
core   +2 more sources

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Dry eye disease and spondyloarthritis: expanding the spectrum of systemic inflammatory disorders associated with ocular surface disease. Data from the international AIDA Network Spondyloarthritis Registry

Frontiers in Medicine
ObjectiveDry eye disease (DED) is a condition associated with a myriad of systemic disorders. According to recent preliminary data, axial spondylarthritis (axial-SpA) could represent a new entity associated with DED. Therefore, this study aimed to assess
Antonio Vitale, Antonio Vitale, Valeria Caggiano, Valeria Caggiano, Eduardo Martín-Nares, Nunzia Di Meglio, Nunzia Di Meglio, Cristian Sica, Cristian Sica, Andrea Hinojosa-Azaola, Maria Orsetta Perfetti, Maria Orsetta Perfetti, Alessandra Pagliara, Alessandra Pagliara, Giorgia Guidetti, Giorgia Guidetti, Alex Fonollosa, Roberta Lopez, Roberta Lopez, Jessica Sbalchiero, Jessica Sbalchiero, Jurgen Sota, Jurgen Sota, Ester Carreño, Ester Carreño, Perla Ayumi Kawakami-Campos, Stefano Gentileschi, Stefano Gentileschi, Alejandra de-la-Torre, Gian Marco Tosi, Gian Marco Tosi, Maria Antonietta Mazzei, Maria Antonietta Mazzei, Alberto Balistreri, Alberto Balistreri, Bruno Frediani, Bruno Frediani, Luca Cantarini, Luca Cantarini, Claudia Fabiani, Claudia Fabiani   +40 more
doaj   +1 more source

A diffuse, pustular eruption in a neonate: Recognizing SAMD9L‐associated autoinflammatory disease (SAAD) [PDF]

, 2023
Melanie M. Miller, Georgina Rowe, Kathleen F. O’Brien, Gene Kim, Minnelly Luu   +4 more
openalex   +1 more source

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, EarlyView.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries

Frontiers in Medicine
IntroductionNon-infectious inflammatory ocular diseases pose significant challenges in diagnosis and management, often requiring systemic immunosuppressive therapy.
Antonio Vitale, Antonio Vitale, Judith Palacios-Olid, Valeria Caggiano, Valeria Caggiano, Gaafar Ragab, Gaafar Ragab, José Hernández-Rodríguez, Laura Pelegrín, Germán Mejía-Salgado, Laura Zarate-Pinzón, Stefano Gentileschi, Stefano Gentileschi, Jurgen Sota, Jurgen Sota, Alex Fonollosa, Ester Carreño, Ester Carreño, Carla Gaggiano, Carla Gaggiano, Rana Hussein Amin, Alberto Balistreri, Alberto Balistreri, Javier Narváez, Gian Marco Tosi, Bruno Frediani, Bruno Frediani, Luca Cantarini, Luca Cantarini, Alejandra de-la-Torre, Claudia Fabiani, Claudia Fabiani   +31 more
doaj   +1 more source

Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. [PDF]

, 2018
BACKGROUND: The pathogenesis of macrophage activation syndrome (MAS) is not clearly understood: a large body of evidence supports the involvement of mechanisms similar to those implicated in the setting of primary hemophagocytic lymphohistiocytosis ...
Bracaglia, Claudia, Caiello, Ivan, Chatel, Laurence, De Min, Cristina, Fabrizio De Benedetti, And, Ferlin, Walter G., Grom, Alexei A., Marasco, Emiliano, Pascarella, Antonia, Prencipe, Giusi, Strippoli, Raffaele   +10 more
core   +1 more source

Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet, Clément Pruvot, Zoé Manssens, Wadih Abou‐Chahla, Sébastien Buche   +4 more
wiley   +1 more source

Dermatologic Findings of RELA‐Associated Autoinflammatory Disease

Pediatric Dermatology, EarlyView.
ABSTRACT Variants in the gene RELA have been implicated in a monogenic, hereditary form of Behcet's‐like syndrome. This case series describes the dermatologic manifestations of three patients with identified RELA‐associated autoinflammatory disease.
Elizabeth Nourse, Vidya Sivaraman, Catherine G. Chung, Shoghik Akoghlanian, Esteban Fernandez Faith   +4 more
wiley   +1 more source