Results 101 to 110 of about 612,706 (397)

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Autologous transplantation and maintenance therapy in multiple myeloma.

New England Journal of Medicine, 2014
BACKGROUND This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide ...
A. Palumbo, F. Cavallo, F. Gay, F. Di Raimondo, D. Ben Yehuda, M. Petrucci, S. Pezzatti, T. Caravita, Chiara Cerrato, E. Ribakovsky, M. Genuardi, A. Cafro, M. Marcatti, L. Catalano, M. Offidani, A. Carella, E. Zamagni, F. Patriarca, P. Musto, A. Evangelista, G. Ciccone, P. Omedè, C. Crippa, P. Corradini, A. Nagler, M. Boccadoro, M. Cavo   +26 more
semanticscholar   +1 more source

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John, Caitlyn Dang, Nidhi Reddy, Calvin Chao, Karen J. Ho, Bin Jiang   +5 more
wiley   +1 more source

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

Annals of the Rheumatic Diseases, 2016
Objectives To assess the safety of intra-articular (IA) autologous tolerogenic dendritic cells (tolDC) in patients with inflammatory arthritis and an inflamed knee; to assess the feasibility and acceptability of the approach and to assess potential ...
G. Bell, A. Anderson, J. Diboll, R. Reece, O. Eltherington, R. Harry, T. Fouweather, C. Macdonald, Thomas Chadwick, E. McColl, J. Dunn, A. Dickinson, C. Hilkens, J. Isaacs   +13 more
semanticscholar   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model

Stem cell research & therapeutics, 2017
BackgroundIntra-articular injection of mesenchymal stem cells (MSCs) is efficacious in osteoarthritis therapy. A direct comparison of the response of the synovial joint to intra-articular injection of autologous versus allogeneic MSCs has not been ...
A. Joswig, Alexis Mitchell, K. Cummings, G. Levine, C. Gregory, Roger D. Smith, A. Watts   +6 more
semanticscholar   +1 more source

Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries [PDF]

, 2016
Aim: The purpose of this study was to investigate the effect of normal synovial fluid (SF) on exposed endogenous tendon-derived cells (TDC) and engrafted mesenchymal stem cells (MSCs) within the tendon extracellular matrix. Methods: Explants from equine
Dudhia, J, Garvican, E R, Salavati, M, Smith, R K W   +3 more
core   +2 more sources

Stack semantics and the comparison of material and structural set theories [PDF]

arXiv, 2010
We extend the usual internal logic of a (pre)topos to a more general interpretation, called the stack semantics, which allows for "unbounded" quantifiers ranging over the class of objects of the topos. Using well-founded relations inside the stack semantics, we can then recover a membership-based (or "material") set theory from an arbitrary topos ...
arxiv  

Salt‐Compact Albumin as a New Pure Protein‐based Biomaterials: From Design to In Vivo Studies

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
A new class of materials built entirely of native albumin protein is designed using a simple protocol based on salt‐assisted compaction, breaking with current crosslinking strategies. This green process leads, surprisingly, to water‐insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that ...
Eya Aloui, Jordan Beurton, Claire Medemblik, Ludivine Hugoni, Igor Clarot, Ariane Boudier, Youri Arntz, Marcella De Giorgi, Jérôme Combet, Guillaume Fleith, Eric Mathieu, Naji Kharouf, Leyla Kocgozlu, Benoît Heinrich, Damien Favier, Michael Brender, Fouzia Boulmedais, Pierre Schaaf, Benoît Frisch, Philippe Lavalle   +19 more
wiley   +1 more source

O transplante de células-tronco hematopoéticas na leucemia linfoide crônica, uma proposta do I Encontro de Diretrizes do Transplante de Medula Óssea da Sociedade Brasileira de Transplante de Medula Óssea, Rio de Janeiro 2009 Hematopoietic stem cell transplantation in chronic lymphoid leukemia: a proposal by the Brazilian Consensus on Bone Marrow Transplantation of the Brazilian Society of Bone Marrow Transplantation, Rio de Janeiro 2009

Revista Brasileira de Hematologia e Hemoterapia, 2010
Portadores de leucemia linfoide crônica (LLC) apresentam curso clínico indolente e prolongado que devem ser diferenciados daqueles que têm doença de evolução agressiva e fatal.
Milton A. Ruiz, José Carlos A. Barros, Rodrigo Santucci, Lilian P. Ruiz, Denis Taveira   +4 more
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