Results 101 to 110 of about 1,070,284 (327)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Full Potential of Future Robotaxis Achievable with Trip-Based Subsidies and Fees Applied to the For-Hire Vehicles of Today [PDF]

, 2019
As described by Grush and Niles in their textbook, The End of Driving: Transportation Systems and Public Policy Planning for Autonomous Vehicles, there are two distinct market states for the future of automobility as vehicles become increasingly ...
Niles, John
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Risk Management Core—Toward an Explicit Representation of Risk in Automated Driving

IEEE Access
While current automotive safety standards provide implicit guidance on how unreasonable risk can be avoided, manufacturers are required to specify risk acceptance criteria for Automated Driving Systems (SAE Level 3 and higher).
Nayel Fabian Salem, Thomas Kirschbaum, Marcus Nolte, Christian Lalitsch-Schneider, Robert Graubohm, Jan Reich, Markus Maurer   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Learning-based Stochastic MPC Design for Cooperative Adaptive Cruise Control to Handle Interfering Vehicles

, 2018
Vehicle to Vehicle (V2V) communication has a great potential to improve reaction accuracy of different driver assistance systems in critical driving situations.
Fallah, Yaser P., Kazemi, Hadi, Mahjoub, Hossein Nourkhiz, Tahmasbi-Sarvestani, Amin   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Optimizing industrial transport with a connected automated vehicle demonstrator for assembly systems and end-of-line production

Scientific Reports
In recent years, the automotive industry has witnessed significant progress in the development of automated driving technologies. The integration of advanced sensors and systems in vehicles has led to the emergence of various functionalities, such as ...
Luis A. Curiel-Ramirez, Tobias Adlon, Peter Burggräf, Ricardo A. Ramirez-Mendoza, Moritz Beyer, Denny Gert   +5 more
doaj   +1 more source

Ist automatisiertes Fahren nachhaltig?

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2018
Automatisiertes Fahren stößt derzeit noch auf große Skepsis. Eine disruptive Strategie bei der Einführung (voll-)automatisierten Fahrens könnte daher auf fehlende Akzeptanz treffen.
Karsten Weber, Sonja Haug
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source