Results 81 to 90 of about 279,436 (276)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Approach and assessment of automated stereotactic radiotherapy planning for early stage non-small-cell lung cancer

BioMedical Engineering OnLine, 2019
Background Intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) are standard physical technologies of stereotactic body radiotherapy (SBRT) that are used for patients with non-small-cell lung cancer (NSCLC).
Xue Bai, Guoping Shan, Ming Chen, Binbing Wang   +3 more
doaj   +1 more source

Getting the best outcomes from epilepsy surgery. [PDF]

, 2018
Neurosurgery is an underutilized treatment that can potentially cure drug-refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes.
Duncan, John S, Elger, Christian E, Engel, Jerome, Staba, Richard, Vakharia, Vejay N, Witt, Juri-Alexander   +5 more
core  

Osteoporotic and Neoplastic Compression Fracture Classification on Longitudinal CT

, 2016
Classification of vertebral compression fractures (VCF) having osteoporotic or neoplastic origin is fundamental to the planning of treatment. We developed a fracture classification system by acquiring quantitative morphologic and bone density ...
Burns, Joseph E., Summers, Ronald M., Wang, Yinong, Yao, Jianhua   +3 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Generating Comfortable, Safe and Comprehensible Trajectories for Automated Vehicles in Mixed Traffic

, 2018
While motion planning approaches for automated driving often focus on safety and mathematical optimality with respect to technical parameters, they barely consider convenience, perceived safety for the passenger and comprehensibility for other traffic ...
Lauer, Martin, Naumann, Maximilian, Stiller, Christoph   +2 more
core   +1 more source

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System [PDF]

Journal of Visualized Experiments, 2018
The Radiation Planning Assistant (RPA) is a system developed for the fully automated creation of radiotherapy treatment plans, including volume-modulated arc therapy (VMAT) plans for patients with head/neck cancer and 4-field box plans for patients with cervical cancer.
Court, Laurence E., Kisling, Kelly, McCarroll, Rachel, Zhang, Lifei, Yang, Jinzhong, Simonds, Hannah, Du Toit, Monique, Trauernicht, Chris, Burger, Hester, Parkes, Jeannette, Mejia, Mike, Bojador, Maureen, Balter, Peter, Branco, Daniela, Steinmann, Angela, Baltz, Garrett, Gay, Skylar, Anderson, Brian, Cardenas, Carlos, Jhingran, Anuja, Shaitelman, Simona, Bogler, Oliver, Schmeller, Kathleen, Followill, David, Howell, Rebecca, Nelson, Christopher, Peterson, Christine, Beadle, Beth   +27 more
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Individualized automated planning for dose bath reduction in robotic radiosurgery for benign tumors.

PLoS ONE, 2019
ObjectTo explore the use of automated planning in robotic radiosurgery of benign vestibular schwannoma (VS) tumors for dose reduction outside the planning target volume (PTV) to potentially reduce risk of secondary tumor induction.MethodsA system for ...
Linda Rossi, Alejandra Méndez Romero, Maaike Milder, Erik de Klerck, Sebastiaan Breedveld, Ben Heijmen   +5 more
doaj   +1 more source