Results 31 to 40 of about 23,271 (259)

An adaptive model predictive approach for automated vehicle control in fallback procedure based on virtual vehicle scheme [PDF]

Journal of Intelligent and Connected Vehicles, 2020
Purpose – Automated driving systems (ADSs) are being developed to avoid human error and improve driving safety. However, limited focus has been given to the fallback behavior of automated vehicles, which act as a fail-safe mechanism to deal with safety ...
Wei Xue, Rencheng Zheng, Bo Yang, Zheng Wang, Tsutomu Kaizuka, Kimihiko Nakano   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Maximizing traffic flow of automated guided vehicles based on Jamology and applications

Advances in Mechanical Engineering, 2018
This study aims to propose and investigate a theoretical maximum traffic flow method. Furthermore, we propose a merging timing control based on the results obtained from this method, which are verified using actual automated guided vehicles. The results (
Kenji Kumagai, Kenji Sawada, Seiichi Shin   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Operational Design Domain-Driven Coverage for the Safety Argumentation of Automated Vehicles

IEEE Access, 2023
Automated Vehicles aim to increase road safety as automated driving systems (ADS) take over the human driving task in the operational design domain (ODD), introducing severe challenges for safety validation.
Patrick Weissensteiner, Georg Stettinger, Siddartha Khastgir, Daniel Watzenig   +3 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Solvent Co‐Intercalation Enabled Ca Storage in MoS2 for Ca‐Ion Batteries

Advanced Functional Materials, EarlyView.
Regulating electrolyte solvation levels enables otherwise non‐intercalatable Ca2+ ions to reversibly co‐intercalate into molybdenum disulfide (MoS2) as ether‐solvated species. The intercalation reversibility is strongly governed by solvent chain length, as demonstrated using diethylene glycol dimethyl ether (G2) and tetraethylene glycol dimethyl ether (
Yudong Luo, Matthias Golomb, Yupei Han, Pan He, Neubi Xavier, Wanjun Ren, Yi Lu, Matthew Hopper, Henry R. Tinker, Qiong Cai, Yang Xu   +10 more
wiley   +1 more source

Legal and Safety Aspects of the Application of Automated and Autonomous Vehicles in the Republic of Croatia

World Electric Vehicle Journal
In its draft proposal for the Road Transport Act, the Croatian government referred to European Union Directive 2022/738, which concerns the use of hired vehicles for goods transport, rather than the pertinent European Union regulations on automated and ...
Melita Milenković, Davor Sumpor, Sandro Tokić   +2 more
doaj   +1 more source

Planning for walking and cycling in an autonomous-vehicle future

Transportation Research Interdisciplinary Perspectives, 2019
Over the last few decades, walking and cycling have increased in the United States, especially in large cities. Future efforts to promote active travel will occur during a time when automated vehicles will increasingly perform driving tasks without human
Bryan Botello, Ralph Buehler, Steve Hankey, Andrew Mondschein, Zhiqiu Jiang   +4 more
doaj   +1 more source