Results 31 to 40 of about 23,538 (260)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Maximizing traffic flow of automated guided vehicles based on Jamology and applications

Advances in Mechanical Engineering, 2018
This study aims to propose and investigate a theoretical maximum traffic flow method. Furthermore, we propose a merging timing control based on the results obtained from this method, which are verified using actual automated guided vehicles. The results (
Kenji Kumagai, Kenji Sawada, Seiichi Shin   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Planning for walking and cycling in an autonomous-vehicle future

Transportation Research Interdisciplinary Perspectives, 2019
Over the last few decades, walking and cycling have increased in the United States, especially in large cities. Future efforts to promote active travel will occur during a time when automated vehicles will increasingly perform driving tasks without human
Bryan Botello, Ralph Buehler, Steve Hankey, Andrew Mondschein, Zhiqiu Jiang   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Operational Design Domain-Driven Coverage for the Safety Argumentation of Automated Vehicles

IEEE Access, 2023
Automated Vehicles aim to increase road safety as automated driving systems (ADS) take over the human driving task in the operational design domain (ODD), introducing severe challenges for safety validation.
Patrick Weissensteiner, Georg Stettinger, Siddartha Khastgir, Daniel Watzenig   +3 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

An adaptive model predictive approach for automated vehicle control in fallback procedure based on virtual vehicle scheme [PDF]

Journal of Intelligent and Connected Vehicles, 2020
Purpose – Automated driving systems (ADSs) are being developed to avoid human error and improve driving safety. However, limited focus has been given to the fallback behavior of automated vehicles, which act as a fail-safe mechanism to deal with safety ...
Wei Xue, Rencheng Zheng, Bo Yang, Zheng Wang, Tsutomu Kaizuka, Kimihiko Nakano   +5 more
doaj   +1 more source

Is an Apple an Orange? A Large Language Model Benchmark for Candidate Term Extraction and Subclass Decisions Against Upper Ontologies in Engineering and Materials Science

Advanced Engineering Materials, EarlyView.
Building machine‐readable vocabularies for materials science is slow, expert‐driven work. This study benchmarks 13 large language models on two of its first steps: finding candidate terms in engineering articles and deciding where they belong in a class hierarchy.
Thomas Bjarsch, Maximilian Holland, Klaus Drechsler, Johannes Schilp   +3 more
wiley   +1 more source

Legal and Safety Aspects of the Application of Automated and Autonomous Vehicles in the Republic of Croatia

World Electric Vehicle Journal
In its draft proposal for the Road Transport Act, the Croatian government referred to European Union Directive 2022/738, which concerns the use of hired vehicles for goods transport, rather than the pertinent European Union regulations on automated and ...
Melita Milenković, Davor Sumpor, Sandro Tokić   +2 more
doaj   +1 more source