Results 41 to 50 of about 73,998 (262)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Automatic RadLex coding of Chinese structured radiology reports based on text similarity ensemble

open access: yesBMC Medical Informatics and Decision Making, 2021
Background Standardized coding of plays an important role in radiology reports’ secondary use such as data analytics, data-driven decision support, and personalized medicine.
Yani Chen   +5 more
doaj   +1 more source

Automatic Czech – Sign Speech Translation [PDF]

open access: yes, 2007
This paper is devoted to the problem of automatic translation between Czech and SC in both directions. We introduced our simple monotone phrase-based decoder - SiMPaD suitable for fast translation and compared its results with the results of the state-of-the-art phrase-based decoder - MOSES.
Kanis, Jakub, Müller, Luděk
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

FROM WORDS TO ERRORS: ANALYZING LEXICAL CHALLENGES IN INSTAGRAM'S MACHINE TRANSLATION OF 'NYTIMES’

open access: yesLire Journal
In the current digital era, disseminating information via social media is very easy and quick, but this can also increase the spread of wrong and inaccurate information to the public caused by translation errors in automatic translations on social media.
I Putu Riky Wiwekananda   +1 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Traitement de l’ambiguïté dans les logiciels de traduction automatique en ligne

open access: yesVoix Plurielles, 2010
Il existe de nos jours plusieurs logiciels de traduction automatique et bon nombre d’entre eux sont accessibles sur l’internet. Ainsi, des moteurs de recherche comme AltaVista ou Yahoo proposent aux internautes d’afficher les pages Web cibles en versions
Jean Ntakirutimana
doaj  

Η Αυτοματοποιημένη και μη-αυτοματοποιημένη αξιολόγηση συστήματος Στατιστικής Μηχανικής Μετάφρασης για το γλωσσικό ζεύγος Ελληνικά - Ιταλικά

open access: yesSyn-Thèses, 2012
Machine Translation (MT) evaluation is a hard task considering the difficulties that raise from the translation process itself. In this paper we present the results of the evaluation of a Statistical Machine Translation (SMT) system in which the Moses ...
Polyxeni Kanelliadou   +1 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

open access: yesFEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti   +5 more
wiley   +1 more source

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