Results 91 to 100 of about 342,046 (278)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Formal Modelling, Testing and Verification of HSA Memory Models using Event-B

, 2016
The HSA Foundation has produced the HSA Platform System Architecture Specification that goes a long way towards addressing the need for a clear and consistent method for specifying weakly consistent memory.
Butler, Michael, Colley, John, Darbari, Ashish, Singleton, Iain   +3 more
core  

Speculative Thread Framework for Transient Management and Bumpless Transfer in Reconfigurable Digital Filters

, 2018
There are many methods developed to mitigate transients induced when abruptly changing dynamic algorithms such as those found in digital filters or controllers.
Ferri, Aldo, Ferri, Bonnie, Giardino, Michael, Maxwell, Wayne   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Load spectrum synthesis and amplitude sequence digitization method of shearer drum cutting coal rock

Meitan xuebao
Shearer working conditions have strong stochastic complex and variable factors, its whole life cycle course of stochastic load spectrum acquisition and discrete sequence processing, as well as the whole domain load spectrum synthesis and digitization is ...
Chunsheng LIU, Shuo CHENG, Chunping REN, Lei WANG, Ruohan LIU, Yanting LIU, Degen LI   +6 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

An enhanced buck-boost converter for photovoltaic diagnosis application: Accurate MPP tracker and I-V tracer

Scientific African
This study introduces a novel dual-functioning buck-boost converter designed for fault detection and diagnosis in photovoltaic (PV) arrays. The adopted control and diagnosis approach enables the converter to operate in two distinct modes depending on the
Yassine Chouay, Mohammed Ouassaid
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Differences in Cerebral Small Vessel Disease Magnetic Resonance Imaging Depending on Cardiovascular Risk Factors: A Retrospective Cross-Sectional Study

Brain Sciences
Background: Vascular risk factors (VRFs) are known to influence cerebral small vessel disease (cSVD) burden and progression. However, their specific impact on the presence and distribution of each cSVD imaging marker (white matter hyperintensity [WMH ...
Marta Ribera-Zabaco, Carlos Laredo, Emma Muñoz-Moreno, Andrea Cabero-Arnold, Irene Rosa-Batlle, Inés Bartolomé-Arenas, Sergio Amaro, Ángel Chamorro, Salvatore Rudilosso   +8 more
doaj   +1 more source