Results 31 to 40 of about 13,227 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Unified Semantic-Dynamic Occupancy Grid Map for Autonomous Vehicles Using LiDAR Semantic Data and Dempster-Shafer Theory

open access: yesIEEE Access
Accurate and comprehensive recognition of dynamic and static objects is essential for the safety and efficiency of autonomous vehicles. However, deep learning-based semantic segmentation, which extracts semantic information from LiDAR point clouds, often
Kyungjae Ahn   +3 more
doaj   +1 more source

CHARACTERISTICS OF ELDERLY SUBMITTED TO DRIVER LICENSE TESTS

open access: yesCogitare Enfermagem, 2017
A quantitative, descriptive and retrospective study was undertaken to screen for the characteristics of elderly people who took the physical and mental aptitude test to get the Brazilian driver license. Data were collected from 1023 forms of elderly aged
Maria Helena Lenardt   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Experimental analysis for behavior and damage of batteries caused by collisions of structure and drones in horizontal flight

open access: yesNihon Kikai Gakkai ronbunshu
This paper aims to clarify the behavior and damage conditions of batteries when multi-rotor unmanned aerial vehicles (drones) in horizontal flight collide with a structure to obtain the engineering knowledge that serves to consider the method of the ...
Kengo TAKAHASHI   +3 more
doaj   +1 more source

International Regulations for Automobile Driving and Epilepsy [PDF]

open access: yesJournal of Travel Medicine, 2006
Many patients with epilepsy travel abroad and drive automobiles with the assumption that policies, rules, and regulations on epilepsy and driving are similar to those of their home countries. This paper investigates the driving restrictions and other pertinent information on this issue in foreign countries.A questionnaire was sent to 231 neurologists ...
W W, Ooi, J A, Gutrecht
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A Review on Fatigue Driving Detection

open access: yesITM Web of Conferences, 2017
The socialization of automobile development has brought great convenience to people’s travel. However, the rapid increase in the number of vehicles has also caused a series of problems.
Shi Sheng-Yang   +2 more
doaj   +1 more source

Development of a weighted scoring system for the Electronic Driving Observation Schedule (eDOS)

open access: yesMethodsX, 2020
The electronic Driving Observation Schedule (eDOS) is a novel approach to assessing older drivers’ performance in their everyday driving environment on their chosen routes.
Yu-Ting Chen   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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