Results 21 to 30 of about 61,376 (305)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
International Journal of Occupational Medicine and Environmental Health, 2017 Objectives: Published reports suggest that some adverse health impact may be related to noise exposure, and motor vehicle traffic is considered to be the main source of environmental hazard of noise.
Michał Skrzypek +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mathematical Modelling of Hybrid Powertrain Systems for Improved Energy Efficiency
CommunicationsThe development and simulation of a mathematical model for a hybrid powertrain vehicle, aiming to optimize its energy efficiency and dynamic performance is presented in this study.
Oleg Lyashuk +8 more
doaj +1 more source
Experimental adsorption and desorption characterization of a gasoline-fueled vehicle carbon canister for European application filled with n-butane and nitrogen mixtures [PDF]
E3S Web of Conferences, 2020 The evaporative emission control system (EVAP system) is the most commonly used strategy to limit the unburned petrol vapor emissions from a gasoline-fueled vehicle fuel tank, in order to comply with the international regulations on Volatile Organic ...
Romagnuolo Luca +7 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Application of micro-grid control system in smart park
The Journal of Engineering, 2019 Micro-grid can be used as a supplement to power supply of large power grids. Combined with smart park, users can easily manage the micro-grid. In the tourist scenic area, the local distributed new energy is mainly used to provide energy for the system ...
Zhang Zhaoyun +7 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Polish Maritime ResearchThis article presents a condensed outline of how approaches to solving technical diagnostics tasks have changed over the last 50 years. It reviews different approaches to the modelling of wear and tear phenomena that are the subject of diagnosis, and ...
Klekot Grzegorz +2 more
doaj +1 more source
Effect of automobiles on global warming: A modeling study [PDF]
, 2017 Global warming threatens our environment as well as basic human needs. In the present scenario, increasing demand and excessive use of automobiles have increased the level of carbon dioxide emission in the environment, providing a significant ...
Ashish Kumar Mishra +2 more
core +1 more source