Results 31 to 40 of about 61,376 (305)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
IET Control Theory & Applications, 2023 The paper proposes the method of uniform flow loading the improved consensus algorithm to achieve obstacle avoidance for multi‐UAV with 3‐D formation. In view of that the flow function is generally only applicable to two dimensional flow field, dimension
Wei Xu, Ning Cao
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Survey on vehicle map matching techniques
CAAI Transactions on Intelligence Technology, 2021 With the development of location‐based services and Big data technology, vehicle map matching techniques are growing rapidly, which is the fundamental techniques in the study of exploring global positioning system (GPS) data.
Zhenfeng Huang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Frontiers in Public HealthRoad traffic injuries (RTIs) represent one of the most concerning and unaddressed public health burdens in Nepal, which disproportionately contributes to premature mortality and disability in a country undergoing rapid motorization.
Samata Nepal +5 more
doaj +1 more source
the impact of electronic automobiles on the Indian automobile
, 2023 The advent of electronic automobiles, also known as electric vehicles (EVs), has brought about a significant shift in the global automotive industry. In India, a country grappling with environmental concerns and a growing need for sustainable transportation solutions, the impact of electronic automobiles on the Indian automobile industry is a topic of ...
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source