Results 31 to 40 of about 278,863 (279)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Assessment of parameters of operability of inductor alternators of automobiles

Интеллект. Инновации. Инвестиции, 2019
The relevance of a problem of diagnosing of alternators is caused by insufficient informational content of the existing diagnosing methods. Automobiles can be equipped with inductor alternators, in which mainly electrical failures occur.
А.V. Puzakov, О.V. Yusupova
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mathematical Modelling of Hybrid Powertrain Systems for Improved Energy Efficiency

Communications
The development and simulation of a mathematical model for a hybrid powertrain vehicle, aiming to optimize its energy efficiency and dynamic performance is presented in this study.
Oleg Lyashuk, Victor Aulin, Roman Rohatynskiy, Ivan Gevko, Andriy Gypka, Dmytro Mironov, Volodymyr Martyniuk, Artur Lutsyk, Nadia Denysiuk   +8 more
doaj   +1 more source

Measuring Quality in Automobile Aftersales: AutoSERVQUAL Scale [PDF]

Amfiteatru Economic, 2017
It is becoming more important to accurately measure the level of quality in services and especially automobile related services such as after sales service.
Yasin Galip Gencer , Ulas Akkucuk
doaj  

Collective behavior of stock price movements in an emerging market

, 2007
To investigate the universality of the structure of interactions in different markets, we analyze the cross-correlation matrix C of stock price fluctuations in the National Stock Exchange (NSE) of India.
H. M. Markowitz, J. P. Bouchaud, L. Bachelier, R. N. Mantegna, Raj Kumar Pan, S. Sinha, Sitabhra Sinha, V. Kulkarni   +7 more
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Construction of the Geometrical Models of a Multiple-Factor Optimization of the Technical and Operating Parameters of the Trolleybuses with an Autonomous Move Margin

Communications, 2022
While introducing into a system of passenger traffic the ecologically clean vehicles, namely the electric buses, a task of providing them with a rational move margin is actual.
Serhii Pustiulha, Volodymyr Samchuk, Valerii Dembitskyi, Viktor Samostian, Valentyn Prydiuk   +4 more
doaj   +1 more source