Results 131 to 140 of about 64,174 (311)

Electrophysiological diagnosis using the coefficient of variation of R‐R intervals and a point‐of‐care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction While treatment for diabetic polyneuropathy (DPN) is still developing, progress has stagnated. The alignment between pathological neurodegeneration in DPN and patients' subjective symptoms is often low, yet these symptoms are frequently used for diagnosis.
Tatsuhito Himeno, Hideki Kamiya, Yuka Shibata, Masato Kase, Hiromi Nakai‐Shimoda, Dai Yamagami, Masahiro Saito, Teruo Jojima, Aiko Arimura, Kenta Murotani, Chieko Suzuki, Hiroki Mizukami, Takahisa Deguchi, Yoshimasa Aso, Jiro Nakamura   +14 more
wiley   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

Impact of glycemic variability on early detection of sudomotor dysfunction: Implications for early intervention and personalized treatment

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background This study investigates the impact of glycemic variability on sudomotor dysfunction in type 2 diabetes mellitus. Methods A total of 206 type 2 diabetes mellitus patients and 34 healthy controls were included. Sweat function (SF) was assessed using electrochemical conductance of hands (HESC) and feet (FESC).
Yang Ou, Xiao‐feng Hu, Zhi Liang, Xiao‐hui Zhang, Yi‐kun Zhou   +4 more
wiley   +1 more source

Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features

American Journal of Medicine Open
Background: Hypermobile Ehlers-Danlos syndrome (hEDS) affects multiple systems, but comprehensive evaluations of a larger sample of hEDS patients are lacking.
Peter Novak, MD, PhD, David M. Systrom, MD, Sadie P. Marciano, PA-C, Alexandra Witte, PA-C, Arabella Warren, MD, PhD, Donna Felsenstein, MD, Matthew P. Giannetti, MD, Matthew J. Hamilton, MD, Jennifer Nicoloro-SantaBarbara, PhD, Mariana Castells, MD, Khosro Farhad, MD, David M. Pilgrim, MD, William J. Mullally, MD, Mark C. Fishman, MD, Jeff M. Milunsky, MD, Aubrey Milunsky, MD, Joel Krier, MD   +16 more
doaj   +1 more source

Diabetic peripheral neuropathy as measured using a point‐of‐care sural nerve conduction device is associated with a faster decline in renal function in patients with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
Point‐of‐care assessment of diabetic peripheral neuropathy with DPN‐Check® was independently associated with a faster decline in renal function in type 2 diabetes, highlighting its potential as a tool to identify patients at high risk of kidney disease progression. ABSTRACT Aims/Introduction Diabetic peripheral neuropathy (DPN) is a common complication
Tatsuya Fukuda, Akiko Fujii, Taro Akihisa, Naoya Otsubo, Tetsuya Yamada, Chisato Maki   +5 more
wiley   +1 more source

Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
In individuals with type 1 diabetes, immune cell infiltration in the colon mucosa tended to correlate with fecal and systemic markers of intestinal permeability and inflammation, as well as gastrointestinal symptoms. These findings suggest that low‐grade gut immune activation might link the intestinal barrier dysfunction with systemic endotoxin ...
Polina Zalizko, Reinis Isaks, Leonora Pahirko, Aleksejs Fedulovs, Eduards Krustins, Jurijs Nazarovs, Sergejs Dubencovs, Hanne Salmenkari, Markku Lehto, Kaspars Jēkabsons, Una Riekstiņa, Per‐Henrik Groop, Niina Sandholm, Jeļizaveta Sokolovska   +13 more
wiley   +1 more source

Significant Microvascular Abnormalities Present in Autonomic Nervous System Dysfunction: Results of a Cross-Sectional Study

Biomedicines
Purpose: The prevalence and phenotype of capillaroscopic abnormalities in patients with autonomic nervous system dysfunction have not yet been investigated. Multiorgan involvement in dysautonomia entails abnormal vasoreactivity.
Sehreen Mumtaz, Karissa Arca, Vikas Majithia, William Cheshire, David Hodge, Florentina Berianu   +5 more
doaj   +1 more source

Decision trees and multi-level ensemble classifiers for neurological diagnostics

, 2014
Cardiac autonomic neuropathy (CAN) is a well known complication of diabetes leading to impaired regulation of blood pressure and heart rate, and increases the risk of cardiac associated mortality of diabetes patients.
Andrei V. Kelarev, Andrew Stranieri, Herbert F. Jelinek, Jemal H. Abawajy, Morshed U. Chowdhury, null null   +5 more
core   +2 more sources

Management of Haws Syndrome in Cats With Gastrointestinal Diet: A Case Series

Veterinary Ophthalmology, EarlyView.
ABSTRACT Background Haws syndrome (HS) in cats is characterized by bilateral protrusion of the third eyelid and ptosis, often accompanied by gastrointestinal (GI) symptoms such as diarrhea. Emerging evidence suggests disruption of the gut‐brain axis, linked to GI microbiota dysbiosis, may play a role in HS development.
Bar Fruchter, Sharon Kuzi, Yamit Soueid, Oren Pe'er, Ron Ofri, Lionel Sebbag   +5 more
wiley   +1 more source

Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes [PDF]

, 2013
Chan‐Hee Jung, Ae-Rin Baek, Kyu-Jin Kim, Bo‐Yeon Kim, Chul‐Hee Kim, Sung‐Koo Kang, Ji‐Oh Mok   +6 more
openalex   +1 more source