Results 101 to 110 of about 95,328 (314)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Legal AI for All: Reducing Perplexity and Boosting Accuracy in Normative Texts With Fine-Tuned LLMs and RAG

IEEE Access
This study investigates the potential of open-source Large Language Models (LLMs) to enhance the accessibility and understanding of complex legal information.
Patricio Santiago Garcia-Montero, Paulina Vizcaino, Ivan Galo Reyes-Chacon, Manuel Eugenio Morocho-Cayamcela   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Developing a Risk Recognition System Based on a Large Language Model for Autonomous Driving

Engineering Proceedings
Autonomous driving systems have the potential to reduce traffic accidents dramatically; however, conventional modules often struggle to accurately detect risks in complex environments.
Donggyu Min, Dong-Kyu Kim
doaj   +1 more source

Study on Following Car Model with Different Driving Styles Based on Proximal PolicyOptimization Algorithm [PDF]

Jisuanji kexue
Autonomous driving plays a crucial role in reducing traffic congestion and improving driving comfort.It remains of significant research importance to enhance public acceptance of autonomous driving technology.Customizing different driving styles for ...
YAN Xin, HUANG Zhiqiu, SHI Fan, XU Heng
doaj   +1 more source

Radar Perception of Multi-Object Collision Risk Neural Domains during Autonomous Driving

The analysis of the state of the literature in the field of methods of perception and control of the movement of autonomous vehicles shows the possibilities of improving them by using an artificial neural network to generate domains of prohibited ...
Józef Lisowski
core   +1 more source

Autonomous Driving in Roundabout Maneuvers Using Reinforcement Learning with Q-Learning

, 2019
Navigating roundabouts is a complex driving scenario for both manual and autonomous vehicles. This paper proposes an approach based on the use of the Q-learning algorithm to train an autonomous vehicle agent to learn how to appropriately navigate ...
Laura García Cuenca, García Cuenca, Laura, Fernández Andrés, Javier, Aliane, Nourdine, Enrique Puertas, Puertas Sanz, Enrique, Javier Fernandez Andrés, Nourdine Aliane   +7 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source