Results 91 to 100 of about 5,784 (283)

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

open access: yesAdvanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen   +7 more
wiley   +1 more source

Lived Experiences of People with and without Disabilities across the Lifespan on Autonomous Shuttles

open access: yesFuture Transportation
As an emerging, alternative mode of transportation, an in-depth understanding of autonomous shuttle (AS) experiences among all age groups, with and without disabilities, may impact acceptance and adoption of the AS, shape industry guidelines, and impact ...
Seung Woo Hwangbo   +4 more
doaj   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

open access: yesAdvanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu   +8 more
wiley   +1 more source

User Experience and Analysis of an Autonomous Shuttle Service

open access: yesProceedings of the 7th International Conference on Vehicle Technology and Intelligent Transport Systems, 2021
Lova Andersson   +6 more
openaire   +1 more source

Environmental life cycle impacts of autonomous e-shuttle busses and consequences for assessing future mobility systems

open access: yes, 2019
The presentations provides LCA (Life-cycle assessment) results on using autonomous electric shuttle busses in public transportation, highlights specific challenges of conducting such assessments, and draws conclusions for more life cycle and ...
Viere, Tobias   +4 more
core   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

open access: yesAdvanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale   +6 more
wiley   +1 more source

Autonomous shuttle bus service timetabling and vehicle scheduling using skip-stop tactic

open access: yes, 2019
The development of new technologies that allow us to know more precisely real-time public transport (PT) passenger demand enables the introduction of new methodologies to improve autonomous shuttle bus service (ASBS) from the perspective of both the user
Cao, Zhichao, Ceder, Avishai (Avi)
core   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

Safety evaluation via conflict classification during automated shuttle bus service operations

open access: yesEuropean Transport Research Review
The widespread adoption of Connected and Automated Vehicles (CAVs) is being propelled, not only in the realm of private vehicles but also within transit systems. This development serves to enhance urban transport activities, rendering transportation more
Apostolos Ziakopoulos   +3 more
doaj   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

open access: yesAdvanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu   +11 more
wiley   +1 more source

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