Results 81 to 90 of about 1,631 (277)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

User experience, safety perceptions, and adoption intentions for autonomous shuttles: findings from a UK trial-phase survey

Frontiers in Future Transportation
IntroductionAutonomous shuttles (AS) are increasingly being tested in real-world environments, yet robust empirical evidence from live UK trials remains limited. This study investigates public awareness, user experience, and behavioural intentions during
Hisham Y. Makahleh, Rachel Johnson, Matthew Shelton, Emma J. S. Ferranti, Christopher D. F. Rogers   +4 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Managing Risk in the Design of Modular Systems for an Autonomous Shuttle

IEEE Open Journal of Intelligent Transportation Systems
This paper presents an analysis and implementation of a robust autonomous driving system for an electric passenger shuttle in shared spaces. We present results of a risk assessment for our vehicle scenario and develop a flexible architecture that integrates safety features and optimises open-source software, facilitating research and operational ...
Thomas H. Drage, Kieran Quirke-Brown, Lemar Haddad, Zhihui Lai, Kai Li Lim, Thomas Bräunl   +5 more
openaire   +4 more sources

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Autonomous Public Transport: Evolution, Benefits, and Challenges in the Future of Urban Mobility

World Electric Vehicle Journal
Autonomous public transport (APT) is revolutionizing urban mobility by integrating advanced technologies, including electric autonomous buses and shared autonomous vehicles (SAVs).
Dalia Hafiz, Mariam AlKhafagy, Ismail Zohdy   +2 more
doaj   +1 more source

Requirements and Test Cycles for Brake Systems of Autonomous Vehicle Concepts on the Example of an Autonomous Shuttle

, 2021
During the development toward autonomous and electrified vehicles with low emissions, many visions for future mobility concepts arise, one of them being autonomous shuttles for urban areas. Most publications concerning these concepts focus on control and
Winner, Hermann, Pla, Sébastien, Guckes, Lennart, Hoffmann, Jens   +3 more
core   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

Development of a Path Tracker Based on a 4WS Vehicle for Low-Speed Automated Driving Systems

Applied Sciences
With the increasing demand for various autonomous driving services in urban environments, low-speed autonomous vehicles, such as autonomous shuttles and purpose-built vehicles, equipped with enhanced driving characteristics suitable for urban roads ...
Heung-Sik Park, Moon-Sik Kim
doaj   +1 more source