Results 61 to 70 of about 48,291 (246)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Research on Game Confrontation of Unmanned Surface Vehicles Swarm Based on Multi-Agent Deep Reinforcement Learning

水下无人系统学报
Based on the background of future modern maritime combats, a multi-agent deep reinforcement learning scheme was proposed to complete the cooperative round-up task in the swarm game confrontation of unmanned surface vehicles (USVs).
Changdong YU, Xinyang LIU, Cong CHEN, Dianyong LIU, Xiao LIANG   +4 more
doaj   +1 more source

Thruster Fault Diagnostics and Fault Tolerant Control for Autonomous Underwater Vehicle with Ocean Currents [PDF]

, 2022
Qunhong Tian, Tao Wang, Bing Liu, Guangtao Ran   +3 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Beliefs and expectations of driving learners about autonomous driving

Transactions on Transport Sciences, 2020
Autonomous driving is a topic that generates great interest and social debate in the field of transport and road safety. Professionals working on vehicle technologies, telecommunications engineers, and vehicle manufacturers say it is an imminent reality ...
Ana Martí-Belda, Patricia Bosó, Ignacio Lijarcio   +2 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

PriorFusion: Unified integration of priors for robust road perception in autonomous driving

Communications in Transportation Research
With the growing interest in autonomous driving, there is an increasing demand for accurate and reliable road perception technologies. In complex environments without high-definition map support, autonomous vehicles must independently interpret their ...
Xuewei Tang, Mengmeng Yang, Tuopu Wen, Peijin Jia, Le Cui, Mingshan Luo, Kehua Sheng, Bo Zhang, Kun Jiang, Diange Yang   +9 more
doaj   +1 more source

CFD prediction of submarine motion during emergency surfacing

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] Emergency surfacing is an important aspect of submarine vitality which is closely related to submarine safety. In order to master the motion laws of submarine during emergency surfacing performance,[Methods] this paper establishes a ...
LI Rijie, CHEN Qinglong, CHANG Wentian
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source