Results 91 to 100 of about 760,872 (260)

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Advancing 6G: Survey for Explainable AI on Communications and Network Slicing

IEEE Open Journal of the Communications Society
The unprecedented advancement of Artificial Intelligence (AI) has positioned Explainable AI (XAI) as a critical enabler in addressing the complexities of next-generation wireless communications.
Haochen Sun, Yifan Liu, Ahmed Al-Tahmeesschi, Avishek Nag, Mohadeseh Soleimanpour, Berk Canberk, Huseyin Arslan, Hamed Ahmadi   +7 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

3D Printing and Surface Engineering of Ti6Al4V Scaffolds for Enhanced Osseointegration in an In Vitro Study

Biomimetics
Ti6Al4V superalloy is recognized as a good candidate for bone implants owing to its biocompatibility, corrosion resistance, and high strength-to-weight ratio. While dense metal implants are associated with stress shielding issues due to the difference in
Changyu Ma, Natan Roberto de Barros, Tianqi Zheng, Alejandro Gomez, Marshall Doyle, Jianhao Zhu, Himansu Sekhar Nanda, Xiaochun Li, Ali Khademhosseini, Bingbing Li   +9 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Distributed Input and State Estimation Using Local Information in Heterogeneous Sensor Networks

Frontiers in Robotics and AI, 2017
A new distributed input and state estimation architecture is introduced and analyzed for heterogeneous sensor networks. Specifically, nodes of a given sensor network are allowed to have heterogeneous information roles in the sense that a subset of nodes ...
Dzung Tran, Tansel Yucelen, Selahattin Burak Sarsilmaz, Sarangapani Jagannathan   +3 more
doaj   +1 more source

Autonomy and Performance of Foreign Subsidiaries in five Transition Countries [PDF]

The paper analyses the link between the autonomy according to business function and the performance of foreign subsidiaries in Slovenia, Poland, Hungary, Slovakia and Estonia.
Urmas Varblane, Helena Hannula, Katrin Männik   +2 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Pregnancy, autonomy and paternalism.

, 1999
Modern medicine is increasingly aware of the significance of patient autonomy in making treatment choices. This would seem to be particularly important where the therapy requested was "voluntary" as in fertility treatment or cosmetic surgery.
G M Lockwood, Lockwood, Gillian M.
core   +1 more source