Results 71 to 80 of about 547,940 (314)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Suitability of a Programme for Improving Interprofessional Primary Care Team Meetings

International Journal of Integrated Care, 2018
Introduction: Primary care is increasingly being confronted with complex health care demands stemming from both biomedical and psychosocial problems of people with chronic diseases.
Jerôme Jean Jacques van Dongen, Marloes Amantia van Bokhoven, Wilhelmus Nicolaas Marie Goossens, Ramon Daniëls, Trudy van der Weijden, Anna Beurskens   +5 more
doaj   +1 more source

Entropy as a Robustness Marker in Genetic Regulatory Networks

Entropy, 2020
Genetic regulatory networks have evolved by complexifying their control systems with numerous effectors (inhibitors and activators). That is, for example, the case for the double inhibition by microRNAs and circular RNAs, which introduce a ubiquitous ...
Mustapha Rachdi, Jules Waku, Hana Hazgui, Jacques Demongeot   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Impacts of Transferring Marine and Fisheries Affairs in West Java Province and Indramayu Regency

Policy & Governance Review, 2018
This article aims to discuss implications prompted by the transfer of administrative affairs in the field of marine and fisheries following the enactment of Law 23 of 2014 on Regional Governance.
Rico Hermawan
doaj   +1 more source

The multiple sources of autonomy as a start-up motive [PDF]

Autonomy is a primary motive for a large majority of small business starters. However, as an explanation of why people want their own (autonomous) business it is largely circular.
Paul Jansen, Marco van Gelderen, Selwyn Jonges   +2 more
core  

Women's autonomy in household decision-making: a demographic study in Nepal

, 2010
Background: How socio-demographic factors influence women's autonomy in decision making on health care including purchasing goods and visiting family and relatives are very poorly studied in Nepal.
van Teijlingen Edwin R, Bell Jacqueline S, Regmi Pramod R, Acharya Dev R, Edwin R van Teijlingen, Simkhada Padam, Simkhada, Padam, Padam Simkhada, Pramod R Regmi, Bell, Jacqui, van Teijlingen, Edwin, Jacqueline S Bell, Regmi, Pramod, Acharya, Dev Raj, Dev R Acharya   +14 more
core   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Robotics, Artificial Intelligence, and Drones in Solar Photovoltaic Energy Applications—Safe Autonomy Perspective

Safety
While there is evidence of substantial improvement in efficiency and cost reduction from the integration of Robotics, Artificial Intelligence, and Drones (RAID) in solar installations; it is observed that there is limited oversight by international ...
Olufemi Olayiwola, Miles Elsden, Mahmoud Dhimish   +2 more
doaj   +1 more source