Results 51 to 60 of about 738,552 (302)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
School autonomy: necessary but not sufficient [PDF]
, 2015 School autonomy has become increasingly significant in the politics of education, as well as a central feature of education systems’ reform policies in Australia and globally. This review examines the spectrum of evidence on the impact of school autonomy
Dahle Suggett
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Psychology of Language and Communication, 2022 The present study takes a self-determination theory perspective (Ryan & Deci, 2017) to explore the connections linking advising in language learning and basic psychological need satisfaction, and ways participation in advising can enhance learner well ...
Shelton-Strong Scott J.
doaj +1 more source
A care perspective on coercion and autonomy [PDF]
, 1999 In the Netherlands there is a growing debate over the possibility of introducing 'compassionate interference' as a form of good psychiatric care. Instead of respecting the autonomy of the patient by adopting an attitude of non-interference, professional ...
Verkerk, M. +3 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Insight Under Scrutiny in the Court of Protection: A Case Law Survey
Frontiers in Psychiatry, 2020 The concept of patient insight, of a patient’s self-awareness of illness or impairment (and related issues), plays a significant role in clinical discourse and clinical practice.
Sándor Gurbai +5 more
doaj +1 more source
Autonomy and commerce: the integration of architectural autonomy
Architectural Research Quarterly, 2007 More than three decades ago, the architectural historian Manfredo Tafuri pessimistically concluded that a revolutionary architecture cannot precede a social revolution. In this comment, he summed up the perceived failure of Modernist architecture to realise a social utopia.
openaire +3 more sources
ON THE AUTONOMY OF THE HEART. [PDF]
JAMA: The Journal of the American Medical Association, 1894 In the last number of theAmerican Journal of Medical Sciences, Prof. I. M. Da Costa has published eight cases of weak heart, where the causation of neurasthenia and organic disorder, as valvular lesion or fatty degeneration had to be excluded. He is inclined to attribute this weakness to the influence of the heart ganglia.
openaire +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source