Results 41 to 50 of about 249,026 (266)

The Autonomy of Affect

Cultural Critique, 1995
Just images, no words, very simple. It was a story depicted in a short shown on German TV as a fill-in between programs. The film drew complaints from parents reporting that their children had been frightened. That drew the attention of a team of researchers.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Design guidelines for assessing students’ interprofessional competencies in healthcare education: a consensus study

Perspectives on Medical Education, 2022
Introduction Healthcare systems require healthcare professionals and students educated in an interprofessional (IP) context. Well-designed assessments are needed to evaluate whether students have developed IP competencies, but we currently lack evidence ...
Hester Wilhelmina Henrica Smeets, Dominique M. A. Sluijsmans, Albine Moser, Jeroen J. G. van Merriënboer   +3 more
doaj   +1 more source

Autonomie of relationele autonomie?

Nederlands Tijdschrift voor Geneeskunde, 2020
Het is een veelvoorkomend misverstand te denken dat het begrip ‘respect voor de autonomie’ betekent dat de patiënt altijd alleen moet beslissen en dat alles wat de patiënt wenst ook moet gebeuren, zonder grenzen. Ook aan het klassieke begrip ‘respect voor autonomie’ zitten grenzen; vrijheid houdt op waar anderen geschaad worden. Bovendien is het begrip
van de Vathorst, Suzanne, Schermer, Maartje   +1 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sustaining language learner well-being and flourishing: A mixed-methods study exploring advising in language learning and basic psychological need support

Psychology of Language and Communication, 2022
The present study takes a self-determination theory perspective (Ryan & Deci, 2017) to explore the connections linking advising in language learning and basic psychological need satisfaction, and ways participation in advising can enhance learner well ...
Shelton-Strong Scott J.
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Temporal Graph Traversals Using Reinforcement Learning With Proximal Policy Optimization

IEEE Access, 2020
Graphs in real-world applications are dynamic both in terms of structures and inputs. Information discovery in such networks, which present dense and deeply connected patterns locally and sparsity globally can be time consuming and computationally costly.
Samuel Henrique Silva, Adel Alaeddini, Peyman Najafirad   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source