Results 101 to 110 of about 57,206 (302)

Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Cell Death and Disease, 2021
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by motoneuron loss, for which there is currently no effective treatment. Statins, as inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are used as drugs
Lin Bai, Yafei Wang, Jia Huo, Shuai Li, Ya Wen, Qi Liu, Jing Yang, Yaling Liu, Rui Li   +8 more
doaj   +1 more source

Autophagy and urothelial carcinoma of the bladder: A review. [PDF]

, 2016
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan, Evans, Christopher P   +1 more
core   +2 more sources

Gintonin stimulates autophagic flux in primary cortical astrocytes

Journal of Ginseng Research, 2020
Gintonin (GT), a novel ginseng-derived exogenous ligand of lysophosphatidic acid (LPA) receptors, has been shown to induce cell proliferation and migration in the hippocampus, regulate calcium-dependent ion channels in the astrocytes, and reduce β-amyloid plaque in the brain.
Md. Ataur Rahman, Hongik Hwang, Seung-Yeol Nah, Hyewhon Rhim   +3 more
openaire   +3 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

MIR376A is a regulator of starvation-induced autophagy [PDF]

, 2013
Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Ali Kosar, B Ravikumar, B Teferedegne, BS Zhao, C le Sage, C Macedo, C Nakada, CJ Foley, D Gozuacik, D Nachmani, Deniz Gulfem Ozturk, Devrim Gozuacik, DJ Klionsky, E Chan, EJ Lee, F Wang, G Bjorkoy, G Korkmaz, G Russo, Gozde Korkmaz, H Seitz, H Siomi, HW Platta, I Tanida, J Hildebrand, J Winter, JS Lee, K Breving, K Duskova, KA Tekirdag, Kumsal Ayse Tekirdag, L Zehavi, LB Frankel, LB Frankel, LM Silva, M Kircher, MD Abramoff, N Mizushima, N Mizushima, N Mizushima, O Oral, Osman Ugur Sezerman, P Mestdagh, PM Voorhoeve, R Faraonio, R Scherz-Shouval, RC Russell, RC Wang, RL Skalsky, S Romao, S Sinha, Sebastien Pfeffer, T Wang, TG McDaneld, V Ambros, V Deretic, X Liu, X Zhang, Y Kabeya, Y Kawahara, Y Ohsumi   +60 more
core   +3 more sources

WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line

Cells, 2020
Autophagy is a cell-survival pathway with dual role in tumorigenesis, promoting either tumor survival or tumor death. WNK2 gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor gene in gliomas, regulating cell migration and invasion; however, its role in autophagy process is poorly explored.
Ana Laura Vieira Alves, Angela Margarida Costa, Olga Martinho, Vinicius Duval da Silva, Peter Jordan, Viviane Aline Oliveira Silva, Rui Manuel Reis   +6 more
openaire   +4 more sources

CAGE Binds to Beclin1, Regulates Autophagic Flux and CAGE-Derived Peptide Confers Sensitivity to Anti-cancer Drugs in Non-small Cell Lung Cancer Cells

Frontiers in Oncology, 2018
The objective of this study was to determine the role of CAGE, a cancer/testis antigen, in resistance of non-small cell lung cancers to anti-cancer drugs.
Minjeong Yeon, Jaewhan Byun, Hyuna Kim, Misun Kim, Hyun Suk Jung, Doyong Jeon, Youngmi Kim, Dooil Jeoung   +7 more
doaj   +1 more source

Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury. [PDF]

, 2019
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury ...
Andres, Allen M, Crupi, Annunziata, Czer, Lawrence S, Esmailian, Fardad, Gottlieb, Roberta A, Hou, Jean, Marek-Iannucci, Stefanie, Mentzer, Robert M, Sin, Jon, Taylor, David J, Thomas, Amandine   +10 more
core  

Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]

, 2019
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S., Coletti, D., de Castro, G. S., Festuccia, W. T., Lima, J. D. C. C., Ortiz-Silva, M., Otoch, J. P., Seelaender, M., Simoes, E., Tokeshi, F.   +9 more
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source