Results 181 to 190 of about 42,282 (208)

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Glucocorticoids Impair the Airway Epithelial Barrier via Autophagy‐Associated Apoptosis in Asthma: A Preliminary Study Both In Vitro and In Vivo

Pediatric Discovery, EarlyView.
Mechanism underlying the negative effects of glucocorticoids on the airway epithelial barrier. Glucocorticoids upregulate autophagy factors and downregulate anti‐autophagy factors. Enhanced autophagy promotes excessive apoptosis and epithelial detachment, impairing airway barrier function.
Hao You, Wenjing Zou, Tangqiaochu Gan, Yu Zhao, Jie Hu, Wen Tan, Ting Wang, Luo Ren, Zhengxiu Luo, Zhou Fu, Chao Niu   +10 more
wiley   +1 more source

PYGL-driven glycogenolysis impairs microglial autophagic flux <i>via</i> SNAP29 <i>O</i>-GlcNAcylation in Alzheimer's disease. [PDF]

Acta Pharm Sin B
Ding Y, Li SY, Zhang WF, Chu MM, Wang XJ, Zhang YG, Zhang HW, Zhang YT, Xu L, Liu X, Morita T, Baba O, Ren ZJ, Zhang YJ, Zhang ZY, Li L.   +15 more
europepmc   +1 more source

Early Growth Response 1‐Associated Epithelial Autophagy‐Related Changes in Allergic Airway Inflammation

Pediatric Discovery, EarlyView.
House dust mite (HDM) exposure induces early growth response 1 (EGR1) expression in airway epithelial cells and is accompanied by autophagy‐associated alterations, including increased LC3B‐II and Vps34 levels and decreased p62 abundance. Manipulation of EGR1 expression modulates these autophagy‐related changes, whereas pharmacological inhibition of ...
Xinyang Wang, Jie Ren, Yan Zhao, Zhengxiu Luo   +3 more
wiley   +1 more source

Autophagy modulation by OmpA-targeted lead compounds restores autophagic flux, reduces biofilm, and enhances immune response in <i>Acinetobacter baumannii</i>-infected pulmonary cells. [PDF]

Microbiol Spectr
Sharma S, Tiwari V.
europepmc   +1 more source

Spermidine mitigates lipopolysaccharide-induced acute lung injury by enhancing autophagic flux. [PDF]

Biomed Rep
Zhang X, Lu H, Xu X.
europepmc   +1 more source

Sodium selenite promotes apoptosis and augments autophagic flux in cervical cancer cells by activating the YAP-Hippo signaling pathway. [PDF]

Transl Cancer Res
Wang C, Zhu K, Bai L, Zhu X.
europepmc   +1 more source

Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation. [PDF]

J Neuroinflammation
Xu S, Liu P, Jia J, Sun M, Ma F, Mao R, Li H, Ji S, Bao X, Xia S, Xu Y, Cao X.   +11 more
europepmc   +1 more source

Impaired Autophagic Flux in Skeletal Muscle of Plectin-Related Epidermolysis Bullosa Simplex With Muscular Dystrophy. [PDF]

J Cachexia Sarcopenia Muscle
Zrelski MM, Eckhard M, Fichtinger P, Hösele S, Sombke A, Mill L, Kustermann M, Schmidt WM, Norwood F, Schlötzer-Schrehardt U, Wiche G, Schröder R, Winter L.   +12 more
europepmc   +1 more source

From Cells to Animals: Connexin43 Suppression Enhances Autophagic Flux to Restore Odontogenesis in Inflamed Dental Pulp. [PDF]

Int Endod J
Hu P, Chen Y, Long P, Zhang A, Lan X, He Y, Li G, Li S.   +7 more
europepmc   +1 more source