Results 201 to 210 of about 57,206 (302)

Impaired Autophagic Flux in Skeletal Muscle of Plectin-Related Epidermolysis Bullosa Simplex With Muscular Dystrophy. [PDF]

J Cachexia Sarcopenia Muscle
Zrelski MM, Eckhard M, Fichtinger P, Hösele S, Sombke A, Mill L, Kustermann M, Schmidt WM, Norwood F, Schlötzer-Schrehardt U, Wiche G, Schröder R, Winter L.   +12 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Erratum: Ambroxol enhances anti-cancer effect of microtubule-stabilizing drug to lung carcinoma through blocking autophagic flux in lysosome-dependent way. [PDF]

Am J Cancer Res
Zhang X, Chen Q, Chen M, Ren X, Wang X, Qian J, Sun Y, Sha X.   +7 more
europepmc   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2. [PDF]

Nat Commun
Karim M, Mishra M, Lo CW, Saul S, Cagirici HB, Gourdelier M, Ghita L, Ojha A, Tran DHN, Agrawal A, McGraw C, East MP, Gammeltoft KA, Sahoo MK, Mooney NA, Johnson GL, Das S, Leyssen P, Neyts J, Chiu W, Cohen CA, Bukh J, Gottwein J, Dye JM, Neff N, Jackson PK, Pinsky BA, Laitinen T, Pantsar T, Poso A, Zanini F, De Jonghe S, Asquith CRM, Einav S.   +33 more
europepmc   +1 more source

Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS‐2B Cells: Viability, Apoptosis, and DNA Damage

Journal of Applied Toxicology, EarlyView.
ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal, Abdullah Burak Karaduman, Büşra Korkut Çelikateş, Merve Güven, Özlem Atlı‐Eklioğlu, Sinem Ilgın   +5 more
wiley   +1 more source

Timosaponin AIII inhibits gastric cancer by causing oxidative stress and blocking autophagic flux. [PDF]

Transl Oncol
Zhu C, Chen S, Lu Y, Song J, Wang S, Guo J, Han X, Fang Y, Zhang S, Qiu W, Qi W.   +10 more
europepmc   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux. [PDF]

J Transl Med
Zhao J, Qiu S, Guo A, Huang H, Wang W, Zhang J.   +5 more
europepmc   +1 more source

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source