Results 311 to 320 of about 1,007,449 (349)

Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO₂ nanoparticles via mTOR-TFEB pathway autophagic flux inhibition. [PDF]

J Nanobiotechnology
Chen H, Liu J, Cao Z, Li J, Zhang H, Yang Q, Cheng J, Shen Y, He K.   +8 more
europepmc   +1 more source

Tetramethylpyrazine attenuates sodium arsenite-induced acute kidney injury by improving the autophagic flux blockade via a YAP1-Nrf2-p62-dependent mechanism. [PDF]

Int J Biol Sci
Song Z, Hei TK, Gong X.
europepmc   +1 more source

Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation. [PDF]

BMC Biol
Chi WY, Lee GH, Tang MJ, Chen BH, Lin WL, Fu TF.   +5 more
europepmc   +1 more source

Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade. [PDF]

Mol Oncol
Phillips E, van Enk S, Kildgaard S, Schlue S, Göttmann M, Jennings V, Bethke F, Müller G, Herold-Mende C, Pastor-Flores D, Schneider M, Helm D, Ostenfeld Larsen T, Goidts V.   +13 more
europepmc   +1 more source

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Assessing autophagic flux in yeast

2021
Abstract Autophagy is an intracellular recycling program that is ubiquitously present in eukaryotes, where it is crucial for the maintenance of cellular homeostasis. Thereby, superfluous or damaged proteins, organelles and cytoplasmic portions are targeted either in bulk or selectively for delivery to the lysosome (or vacuole in yeast).
Katharina, Kainz, Tobias, Pendl, Frank, Madeo, Didac, Carmona-Gutierrez   +3 more
openaire   +2 more sources

Autophagic flux assessment by immunoblot

2021
Autophagy is one of the main adaptive mechanisms to maintain cellular homeostasis in response to multiple stresses. During autophagy diverse cellular components such as damaged organelles or superfluous proteins are targeted for lysosomal degradation.
Qi, Wu, Ai-Ling, Tian, Hui, Pan, Oliver, Kepp, Guido, Kroemer   +4 more
openaire   +2 more sources

Silver nanoparticle-induced impaired autophagic flux and lysosomal dysfunction contribute to the microglia inflammation polarization.

Food and Chemical Toxicology, 2022
Silver nanoparticles (AgNPs) have been incorporated in many consumer and biomedical products. Serious concerns have been expressed about the environmental and public health risks caused by nanoparticles.
Mengting Shang, Shuyan Niu, Xiaoru Chang, Jiangyan Li, Wenli Zhang, Menghao Guo, Tianshu Wu, Ting Zhang, M. Tang, Yuying Xue   +9 more
semanticscholar   +1 more source

Measuring Autophagic Cargo Flux with Keima-Based Probes.

Methods in molecular biology, 2022
Autophagy and autophagy-associated genes are implicated in a growing list of cellular, physiological, and pathophysiological processes and conditions. Therefore, it is ever more important to be able to reliably monitor and quantify autophagic activity. Whereas autophagic markers, such as LC3 can provide general indications about autophagy, specific and
N. Engedal, Tonje Sønstevold, C. J. Beese, Sarvini Selladurai, Thea Melcher, Julia E Simensen, Lisa B. Frankel, A. Urbanucci, M. Torgersen   +8 more
semanticscholar   +4 more sources

Autophagic flux in glioblastoma cells

International Journal of Radiation Biology, 2016
To establish metabolic context for radiation sensitivity by measuring autophagic flux in two different glioblastoma (GBM) cell lines. Clonogenic survival curve analysis of U87 or U251 cells exposed to γ radiation, fast neutrons, a mixed energy neutron beam (METNB) or Auger electrons from a gadolinium neutron capture (GdNC) reaction suggested other ...
Linda S, Yasui, Maria, Duran, Christine, Andorf, Thomas, Kroc, Kathryn, Owens, Kelsie, Allen-Durdan, Andrew, Schuck, Scott, Grayburn, Richard, Becker   +8 more
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Autophagic Flux Detection: Significance and Methods Involved

2021
Macroautophagy is an important biological process in eukaryotic cells by which longevity proteins, misfolded proteins, and damaged organelles are degraded. The autophagy process consists of three key steps: (1) the formation of autophagosomes; (2) the fusion of the autophagosomes with lysosomes; and (3) the degradation of the contents of autolysosomes.
Xiao-Wei, Zhang, Xiao-Xi, Lv, Ji-Chao, Zhou, Cai-Cai, Jin, Lu-Yao, Qiao, Zhuo-Wei, Hu   +5 more
openaire   +2 more sources