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Analyzing Autophagic Flux in Nerve Cultures
2018Autophagy is a key cellular mechanism involved in the degradation of long-lived proteins and organelles. We and others have previously shown that Schwann cells are able to degrade their own myelin by a form of selective autophagy, or myelinophagy.
Miguel, Tamayo Caro +5 more
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Science Signaling, 2016
TLR9 recognizing mitochondrial DNA sustains autophagic flux by functioning as a signaling adaptor protein at lysosomes.
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TLR9 recognizing mitochondrial DNA sustains autophagic flux by functioning as a signaling adaptor protein at lysosomes.
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Autophagic Flux Assessment in Colorectal Cancer Cells
2018Autophagy protects colorectal cancer cells against therapeutic intervention. Autophagy is a continuous process, and autophagic flux requires both autophagosome synthesis and their subsequent degradation at lysosomes. Hence, cells with elevated autophagic flux display both rapid autophagosome generation and degradation.
Annie, Lauzier, Steve, Jean
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Autophagy and Autophagic Flux in Tumor Cells
2014Macroautophagy (hereafter referred to as autophagy), a central mechanism mediating the lysosomal degradation of cytoplasmic components, can be stimulated by a wide panel of adverse stimuli, including a panoply of anticancer agents. The central autophagic organelle is the autophagosome, a double membrane-bound vacuole that sequesters the cytoplasmic ...
Nicolas, Dupont +3 more
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Autophagic flux determination in vivo and ex vivo
Methods, 2015Autophagy is a highly dynamic process that mediates the degradation of cellular constituents inside lysosomes. It is characterized by the formation of autophagosomes, double membrane organelles that engulf cytosolic components and organelles and degrade their contents upon fusion with lysosomes. Upregulation of autophagy in response to specific stimuli
Lorena, Esteban-Martínez +1 more
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Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux
Journal of Visualized Experiments, 2019Cells employ several methods for recycling unwanted proteins and other material, including lysosomal and non-lysosomal pathways. The main lysosome-dependent pathway is called autophagy, while the primary non-lysosomal method for protein catabolism is the ubiquitin-proteasome system.
Mikhail, Ryzhikov +2 more
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RLIP76 Depletion Enhances Autophagic Flux in U251 Cells
Cellular and Molecular Neurobiology, 2016Our previous study showed that RalA-binding protein 1 (RLIP76) is overexpressed in gliomas and is associated with higher tumour grade and decreased patient survival. Furthermore, RLIP76 downregulation increases chemosensitivity of glioma cells to temozolomide by inducing apoptosis.
Chenran, Zhang +6 more
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[New methods to detect autophagic flux].
Yao xue xue bao = Acta pharmaceutica Sinica, 2016Autophagy is a crucial biological process of eukaryotes, which is involved in cell growth, survival and energy metabolism, while the premise of the autophagy function is activated autophagic flux. It has been confirmed that impaired autophagic flux promotes pathogenesis of many chronic inflammatory diseases, especially cancer, neurodegenerative disease
Xiao-xi, Lü, Zhuo-wei, Hu
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Autophagic Flux in Gestational Diabetes Mellitus
Zeitschrift für Geburtshilfe und Neonatologie, 2021J Stepan +5 more
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