Results 271 to 280 of about 5,550,027 (295)

Regulation of autophagosome formation by Rho kinase

Cellular Signalling, 2013
Macroautophagy, commonly referred to as autophagy, is a protein degradation pathway that functions at a constitutive level in cells, which may become further activated by stressors such as nutrient starvation or protein aggregation. Autophagy has multiple beneficial roles for maintaining normal cellular homeostasis and these roles are related to the ...
Mleczak, Andrzej, Millar, Sarah, Tooze, Sharon A, Olson, Michael F, Chan, Edmond Y W   +4 more
openaire   +4 more sources

Interruption of Autophagosome Formation in Cardiovascular Disease, an Evidence for Protective Response of Autophagy

Immunological Investigations, 2020
Background: A heart attack occurs when coronary artery blockage interrupts the blood supply to the heart such as is seen in cardiovascular disease (CVD).
Hany Khalil, Ahmed I. Abd El Maksoud, Amira Alian, W. El-Hamady, A. Daif, A. Awad, A. Guirgis   +6 more
semanticscholar   +1 more source

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

Molecular Cell, 2017
Yan G Zhao, Nan Liu, Pingsheng Liu
exaly   +2 more sources

Autophagosome Formation and Molecular Mechanism of Autophagy

Antioxidants & Redox Signaling, 2011
Autophagy (macroautophagy), or the degradation of large numbers of cytoplasmic components, is induced by extracellular and intracellular signals, including oxidative stress, ceramide, and endoplasmic reticulum stress. This dynamic process involves membrane formation and fusion, including autophagosome formation, autophagosome-lysosome fusion, and the ...
openaire   +2 more sources

WIPI2b and Atg16L1: setting the stage for autophagosome formation

Biochemical Society Transactions, 2014
The double-membraned autophagosome organelle is an integral part of autophagy, a process that recycles cellular components by non-selectively engulfing and delivering them to lysosomes where they are digested. Release of metabolites from this process is involved in cellular energy homoeostasis under basal conditions and during nutrient starvation ...
Michael I, Wilson, Hannah C, Dooley, Sharon A, Tooze   +2 more
openaire   +2 more sources

Amino Acid Regulation of Autophagosome Formation

2008
Amino acids are not only substrates for various metabolic pathways, but can also serve as signaling molecules controlling signal transduction pathways. One of these signaling pathways is mTOR-dependent and is activated by amino acids (leucine in particular) in synergy with insulin. Activation of this pathway inhibits autophagy.
openaire   +3 more sources

Assessment of Autophagosome Formation by Transmission Electron Microscopy

2011
Autophagy is a complex degradative process by which cytosolic material, including organelles, is randomly sequestered within double-membrane bound vesicles termed autophagosomes and targeted for degradation. Initially described as a nutrient stress adaptation response, the process of autophagy is now recognized as a central mechanism involved in many ...
Marina, Nadal, Scott E, Gold
openaire   +2 more sources

Different roles of ACSL3 and ACSL4 in autophagosome formation

Journal of Cell Science
ABSTRACT Acyl-CoA synthetases (ACSLs) are a family of enzymes that convert intracellular fatty acids into acyl-CoA. A previous study has demonstrated that the yeast ACSL Faa1 (a homolog of mammalian ACSL4) is involved in autophagosome membrane elongation.
Shun Kato, Naoki Okada, Toshiki Ohata, Takefumi Uemura, Satoshi Waguri, Yuichi Wakana, Hiroki Inoue, Kohei Arasaki, Mitsuo Tagaya   +8 more
openaire   +2 more sources

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

Nature Structural & Molecular Biology, 2019
T. Osawa, T. Kotani, Tatsuya Kawaoka, Eri Hirata, Kuninori Suzuki, H. Nakatogawa, Y. Ohsumi, N. Noda   +7 more
semanticscholar   +1 more source

Autophagosome Formation

2016
Eleftherios Karanasios, Nicholas T. Ktistakis   +1 more
openaire   +1 more source