Results 61 to 70 of about 9,652,270 (258)

Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation.

Molecules and Cells
In multicellular organisms, very little is known about how Ca2+ transients on the ER outer surface elicited by autophagy stimuli are sustained and decoded to trigger autophagosome formation.
Q. Zheng, Huan Zhang, Hong-Yu Zhao, Yong Chen, Hongzhining Yang, Tingting Li, Qixu Cai, Ying-Yu Chen, You-Jun Wang, Mingjie Zhang, Hong Zhang   +10 more
semanticscholar   +1 more source

Phospholipids in Autophagosome Formation and Fusion [PDF]

, 2016
Autophagosomes are double-membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation.
Nakamura, Shuhei, Yoshimori, Tamotsu, Martens, Sascha   +2 more
core   +1 more source

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

Communicative & Integrative Biology, 2018
Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation.
Megha Bansal, Shivranjani C Moharir, Ghanshyam Swarup   +2 more
doaj   +1 more source

Silencing of LLGL2 Suppresses the Estradiol-Induced BPH-1 Cell Proliferation through the Regulation of Autophagy

Biomedicines, 2022
Lethal giant larvae (Lgl) is an apical-basal polarity gene first identified in Drosophila. LLGL2 is one of the mammalian homologs of Lgl. However, little is known about its function in the prostate.
Kyung-Hyun Kim, Geum-Lan Hong, Yae-Ji Kim, Hui-Ju Lee, Ju-Young Jung   +4 more
doaj   +1 more source

Autophagosome maturation in primary rat hepatocytes. [PDF]

, 2006
Nutrient deprivation of eukaryotic cells elicits a rapid survival response, including the induction of autophagy. Autophagy, or "self-eating", involves the formation of autophagosomes from an unknown membrane source and the sequestration of cytosolic ...
Kchl, R., Köchl, Robert
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The N-terminal region of the human autophagy protein ATG16L1 contains a domain that folds into a helical structure consistent with formation of a coiled-coil. [PDF]

PLoS ONE, 2013
Autophagy is a fundamental cellular process required for organelle degradation and removal of invasive pathogens. Autophagosome formation involves the recruitment of, and interaction between, multiple proteins produced from autophagy-related (ATG) genes.
Rhiannon Parkhouse, Ima-Obong Ebong, Carol V Robinson, Tom P Monie   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

PlAtg8-mediated autophagy regulates vegetative growth, sporangial cleavage, and pathogenesis in Peronophythora litchii

Microbiology Spectrum
Autophagy is a conserved cellular metabolic process in eukaryotes that transports damaged or redundant intracellular organelles and proteins to lysosomes or vacuoles for degradation and recycling.
Ge Yu, Wenqiang Li, Chengdong Yang, Xue Zhang, Manfei Luo, Taixu Chen, Xuejian Wang, Rongbo Wang, Qinghe Chen   +8 more
doaj   +1 more source

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates

Molecules and Cells, 2019
Summary The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
E. Turco, M. Witt, C. Abert, T. Bock-Bierbaum, Ming-Yuan Su, Riccardo Trapannone, Martin Sztacho, Alberto Danieli, Xiaoshan Shi, Gabriele Zaffagnini, Annamaria Gamper, Martina Schuschnig, Dorotea Fracchiolla, Daniel Bernklau, J. Romanov, M. Hartl, J. Hurley, O. Daumke, S. Martens   +18 more
semanticscholar   +1 more source