Results 61 to 70 of about 5,550,027 (295)
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion
Autophagy, 2022 SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy.
Hong Huang +6 more
semanticscholar +1 more source
Autophagosome formation is required for cardioprotection by chloramphenicol [PDF]
Life Sciences, 2017 Chloramphenicol (CAP), a broad spectrum antibiotic, was shown to protect the heart against ischemia/reperfusion (I/R) injury. CAP also induces autophagy, however, it is not known whether CAP-induced cardioprotection is mediated by autophagy. Therefore, here we aimed to assess whether activation of autophagy is required for the infarct size limiting ...
Zoltán Giricz +7 more
openaire +4 more sources
Regulation of actin nucleation and autophagosome formation [PDF]
Cellular and Molecular Life Sciences, 2016 Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during ...
Coutts, A, La Thangue, N
openaire +4 more sources
Communicative & Integrative Biology, 2018 Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation.
Megha Bansal +2 more
doaj +1 more source
The N-terminal region of the human autophagy protein ATG16L1 contains a domain that folds into a helical structure consistent with formation of a coiled-coil. [PDF]
PLoS ONE, 2013 Autophagy is a fundamental cellular process required for organelle degradation and removal of invasive pathogens. Autophagosome formation involves the recruitment of, and interaction between, multiple proteins produced from autophagy-related (ATG) genes.
Rhiannon Parkhouse +3 more
doaj +1 more source
Biomedicines, 2022 Lethal giant larvae (Lgl) is an apical-basal polarity gene first identified in Drosophila. LLGL2 is one of the mammalian homologs of Lgl. However, little is known about its function in the prostate.
Kyung-Hyun Kim +4 more
doaj +1 more source
Aging Cell, 2020 Advancing age is a major risk factor for developing heart disease, and the biological processes contributing to aging are currently under intense investigation.
Wenjing Liang +5 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Atg41/Icy2 regulates autophagosome formation [PDF]
Autophagy, 2015 Macroautophagy (hereafter autophagy) is one of the major degradation systems in eukaryotic cells, and its dysfunction may result in diseases ranging from neurodegeneration to cancer. Although most of the autophagy-related (Atg) proteins that function in this pathway were first identified in yeast, many were subsequently shown to have homologs in higher
Zhiyuan, Yao +3 more
openaire +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source