Results 41 to 50 of about 9,652,270 (258)

Ole1, fatty acid desaturase, is required for Atg9 delivery and isolation membrane expansion during autophagy in Saccharomyces cerevisiae

Biology Open, 2017
Macroautophagy, a major degradation pathway of cytoplasmic components, is carried out through formation of a double-membrane structure, the autophagosome. Although the involvement of specific lipid species in the formation process remains largely obscure,
Yuta Ogasawara, Shintaro Kira, Yukio Mukai, Takeshi Noda, Akitsugu Yamamoto   +4 more
doaj   +1 more source

Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes. [PDF]

PLoS ONE, 2016
Autophagy acts as a host-defense system against pathogenic microorganisms such as Group A Streptococcus (GAS). Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase ...
Seiichiro Oda, Takashi Nozawa, Atsuko Nozawa-Minowa, Misako Tanaka, Chihiro Aikawa, Hiroyuki Harada, Ichiro Nakagawa   +6 more
doaj   +1 more source

Origin of the Autophagosomal Membrane in Plants

Frontiers in Plant Science, 2016
During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang, Kin Pan CHUNG, Liwen Jiang, Liwen Jiang   +3 more
doaj   +1 more source

Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1

Signal Transduction and Targeted Therapy, 2021
Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation.
Wenchang Xiao, Danna Yeerken, Jia Li, Zhangfu Li, Lanfang Jiang, Dan Li, Ming Fu, Liying Ma, Yongmei Song, Weimin Zhang, Qimin Zhan   +10 more
doaj   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
Williams, Roderick A M, Mottram, Jeremy C, Roderick A M Williams, Benjamin Cull, Mottram Jeremy C., Coombs, Graham H, Williams Roderick A. M., Cull Benjamin, Terry K Smith, Jeremy C. Mottram (112563), Graham H. Coombs (164011), Smith Terry K., Terry K. Smith (112550), Mottram, Jeremy C., Benjamin Cull (164010), Coombs Graham H., Coombs, Graham H., Smith, Terry K., Jeremy C Mottram, Smith, Terry K, Cull, Benjamin, Williams, Roderick A. M., Roderick A. M. Williams (164005), Graham H Coombs   +23 more
core   +1 more source

Autophagosome formation machinery.

, 2023
(1) The initiation of autophagosome formation requires the activation of the ULK complex (composed of ULK1/2 (unc-51-like kinases 1 and 2), ATG13, ATG101, and FIP200 (also known as RB1CC1)), which further activates ATG13 inducing its translocation to the
Jérémy Verbeke (5396666), Xavier De Bolle (6943391), Thierry Arnould (122707)   +2 more
core   +1 more source

Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy

Frontiers in Cell and Developmental Biology, 2022
A growing body of evidence suggests that neutrophil extracellular traps (NETs) critically contribute to the development of atherosclerosis. However, the detailed mechanism of how NETs promote atherogenesis remains unknown.
Masataka Sano, Masataka Sano, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano   +8 more
doaj   +1 more source

Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation

Molecules and Cells, 2021
Summary Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by using de novo double-membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar ...
Anne Schreiber, Ben C. Collins, Colin Davis, Radoslav I. Enchev, Angie Sedra, Rocco D'Antuono, R. Aebersold, M. Peter   +7 more
semanticscholar   +1 more source

A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors.

PLoS Pathogens, 2022
Viruses can hijack autophagosomes as the nonlytic release vehicles in cultured host cells. However, how autophagosome-mediated viral spread occurs in infected host tissues or organs in vivo remains poorly understood.
Dongsheng Jia, Qifu Liang, Huan Liu, Guangjun Li, Xiaofeng Zhang, Qian Chen, Aiming Wang, Taiyun Wei   +7 more
doaj   +1 more source

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila [PDF]

, 2008
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3)) – kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear.
Backer, J. M., Baehrecke, EH, Miklós Sass, Hill, JH, Ying Yan, Hill, J. H., Sass, Miklós, Jahda H. Hill, Backer, JM, Gábor Juhász, Thomas P. Neufeld, Jonathan M. Backer, Baehrecke, E. H., Yan, Y, Neufeld, TP, Juhász, Gábor, Yan, Y., Neufeld, T. P., Eric H. Baehrecke   +18 more
core   +1 more source