Results 21 to 30 of about 5,550,027 (295)

Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models

Cells, 2020
Recent findings have shown that the connectivity and crosstalk between mitochondria and the endoplasmic reticulum (ER) at mitochondria–ER contact sites (MERCS) are altered in Alzheimer’s disease (AD) and in AD-related models.
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Luana Naia, Antonio Piras, Caroline Graff, Antonio Cattaneo, Giovanni Meli, Maho Hamasaki, Per Nilsson, Maria Ankarcrona   +10 more
doaj   +2 more sources

Autophagy-related protein PlATG2 regulates the vegetative growth, sporangial cleavage, autophagosome formation, and pathogenicity of peronophythora litchii [PDF]

Virulence
Autophagy is an intracellular degradation process that is important for the development and pathogenicity of phytopathogenic fungi and for the defence response of plants.
Lin Lv, Chengdong Yang, Xue Zhang, Taixu Chen, Manfei Luo, Ge Yu, Qinghe Chen   +6 more
doaj   +2 more sources

Local membrane source gathering by p62 body drives autophagosome formation. [PDF]

Nat Commun, 2023
Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms ...
Feng X, Sun D, Li Y, Zhang J, Liu S, Zhang D, Zheng J, Xi Q, Liang H, Zhao W, Li Y, Xu M, He J, Liu T, Hasim A, Ma M, Xu P, Mi N.   +17 more
europepmc   +2 more sources

STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy. [PDF]

EMBO J, 2023
The cGAS‐STING pathway plays an important role in host defense by sensing pathogen DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of autophagosome formation in cGAS‐STING pathway‐induced autophagy is still unclear ...
Wan W, Qian C, Wang Q, Li J, Zhang H, Wang L, Pu M, Huang Y, He Z, Zhou T, Shen HM, Liu W.   +11 more
europepmc   +2 more sources

Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance [PDF]

Proc Natl Acad Sci U S A
Ka Kit Chung, Kai Ching Law, Ziwei Zhao, Juncai Ma, Xiaohong Zhan, Cheuk Him Chiang, Kwan Ho Leung, Ruben Shrestha, Yixin Wu, Chaorui Li, Ka Ming Lee, Lei Feng, Xibao Li, Kam‐Bo Wong, Shou‐Ling Xu, Caiji Gao, Xiaohong Zhuang   +16 more
openalex   +2 more sources

Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy. [PDF]

Sci Signal, 2023
The degradation of macromolecules and organelles by the process of autophagy is critical for cellular homeostasis and is often compromised during aging and disease.
Quiles JM, Najor RH, Gonzalez E, Jeung M, Liang W, Burbach SM, Zumaya EA, Diao RY, Lampert MA, Gustafsson ÅB.   +9 more
europepmc   +2 more sources

Aging Differentially Affects Axonal Autophagosome Formation and Maturation. [PDF]

Autophagy, 2023
Misregulation of neuronal autophagy has been implicated in age-related neurodegenerative diseases including Parkinson’s disease and Huntington’s disease.
Tsong H, Holzbaur EL, Stavoe AK.
europepmc   +2 more sources

Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation [PDF]

Int J Biol Sci
Tianxin Xiong, Yi Li, Molin Yang, Bo Huo, Xian Guo, Liyuan Liu, Yanxin Huang, Xuehai Zhu, Qinghua Hu, Xiang Wei, Ding‐Sheng Jiang, Xin Yi   +11 more
openalex   +2 more sources

VAMP724 and VAMP726 are involved in autophagosome formation in Arabidopsis thaliana. [PDF]

Autophagy, 2023
Macroautophagy/autophagy, an evolutionarily conserved degradative process essential for cell homeostasis and development in eukaryotes, involves autophagosome formation and fusion with a lysosome/vacuole.
He Y, Gao J, Luo M, Gao C, Lin Y, Wong HY, Cui Y, Zhuang X, Jiang L.   +8 more
europepmc   +2 more sources

Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling. [PDF]

Mil Med Res, 2022
Background Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy.
Li MZ, Liu EJ, Zhou QZ, Li SH, Liu SJ, Yu HT, Pan QH, Sun F, He T, Wang WJ, Ke D, Feng YQ, Li J, Wang JZ.   +13 more
europepmc   +2 more sources