BCAS-3 is required for the progression of autophagosome formation to degrade paternal mitochondria in Caenorhabditis elegans [PDF]
iScienceSummary: In the nematode Caenorhabditis elegans, autophagy degrades paternal mitochondria after fertilization to ensure the maternal inheritance of mitochondrial DNA.
Takuya Norizuki +7 more
doaj +2 more sources
Transmembrane phospholipid translocation mediated by Atg9 is involved in autophagosome formation. [PDF]
J Cell Biol, 2021 Orii et al. show that phospholipids distribute symmetrically in the yeast autophagosomal membranes. They also show that de novo–synthesized phosphatidylcholine is incorporated to autophagosomal membranes preferentially and attains the symmetrical ...
Orii M +3 more
europepmc +2 more sources
Regulators of autophagosome formation in Drosophila muscles. [PDF]
PLoS Genetics, 2015 Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role of putative autophagy regulators in the specific ...
Jonathan Zirin +4 more
doaj +2 more sources
SEC31a‐ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation [PDF]
Advanced ScienceAutophagy plays an important role in determining stem‐cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown.
Jiaming Nie +9 more
doaj +2 more sources
Cells, 2020 Recent findings have shown that the connectivity and crosstalk between mitochondria and the endoplasmic reticulum (ER) at mitochondria–ER contact sites (MERCS) are altered in Alzheimer’s disease (AD) and in AD-related models.
Nuno Santos Leal +10 more
doaj +2 more sources
Emerging roles of ATG proteins and membrane lipids in autophagosome formation
Cell Discovery, 2020 Autophagosome biogenesis is a dynamic membrane event, which is executed by the sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup-shaped membrane structure appears in the cytoplasm, then elongates sequestering ...
Taki Nishimura, S. Tooze
semanticscholar +3 more sources
An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. [PDF]
PLoS Pathogens, 2009 Group A streptococcus (GAS; Streptococcus pyogenes) is a common pathogen that invades non-phagocytic human cells via endocytosis. Once taken up by cells, it escapes from the endocytic pathway to the cytoplasm, but here it is contained within a membrane ...
Hitomi Yamaguchi +5 more
doaj +2 more sources
Does Coxsackievirus B3 Require Autophagosome Formation for Replication? Evidence for an Autophagosome-Independent Mechanism: Insights into Its Limited Potential as a Therapeutic Target [PDF]
PharmaceuticalsBackground/Objectives: Coxsackievirus B3 (CVB3), a neurotropic enterovirus, is a major causative agent of viral encephalitis and myocarditis, yet no protective vaccine or effective antiviral therapy is currently available.
Yun Ji Ga, Jung-Yong Yeh
doaj +2 more sources
Autophagy-related protein PlATG2 regulates the vegetative growth, sporangial cleavage, autophagosome formation, and pathogenicity of peronophythora litchii [PDF]
VirulenceAutophagy is an intracellular degradation process that is important for the development and pathogenicity of phytopathogenic fungi and for the defence response of plants.
Lin Lv +6 more
doaj +2 more sources
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction
Autophagy, 2019 TP53INP2/DOR (tumor protein p53-inducible nuclear protein 2) contributes to mammalian macroautophagy/autophagy by carrying nuclear deacetylated MAP1LC3/LC3 to the cytoplasm.
Wei Wan, Zhiyuan You, Tianhua Zhou
exaly +2 more sources