Mechanisms of autophagosome formation [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThe formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis.
Yuko FUJIOKA, Nobuo N. NODA
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STING recruits WIPI2 for autophagosome formation [PDF]
Autophagy, 2023 Induction of autophagy is a primordial function of the cGAS-STING pathway. However, the molecular mechanisms regulating autophagosome formation during STING-induced autophagy remain largely unknown.
Wei Wan
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Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana [PDF]
Nature Communications, 2022 Autophagosomes are specialized vesicles that target and deliver cargo to the lytic vacuole. Here the authors show that plasma-membrane derived lipid phosphatidylinositol-4-phosphate supports the assembly and expansion of autophagosomes in ...
Rodrigo Enrique Gomez +9 more
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Modeling Membrane Morphological Change during Autophagosome Formation [PDF]
iScience, 2020 Summary: Autophagy is an intracellular degradation process that is mediated by de novo formation of autophagosomes. Autophagosome formation involves dynamic morphological changes; a disk-shaped membrane cisterna grows, bends to become a cup-shaped ...
Yuji Sakai +4 more
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Autophagosome formation in relation to the endoplasmic reticulum [PDF]
Journal of Biomedical Science, 2020 Autophagy is a process in which a myriad membrane structures called autophagosomes are formed de novo in a single cell, which deliver the engulfed substrates into lysosomes for degradation.
Yo-hei Yamamoto, Takeshi Noda
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Local membrane source gathering by p62 body drives autophagosome formation. [PDF]
Nat Commun, 2023 Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms ...
Feng X +17 more
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STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy. [PDF]
EMBO J, 2023 The cGAS‐STING pathway plays an important role in host defense by sensing pathogen DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of autophagosome formation in cGAS‐STING pathway‐induced autophagy is still unclear ...
Wan W +11 more
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Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation. [PDF]
J Cell Biol, 2023 Broadbent, Barnaba et al. analyze autophagy in living cells using HaloTagged autophagy factors to provide quantitative insight into autophagosome biogenesis, including the role of ATG2-mediated membrane tethering in the initiation of phagophores and the ...
Broadbent DG +3 more
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Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy. [PDF]
Sci Signal, 2023 The degradation of macromolecules and organelles by the process of autophagy is critical for cellular homeostasis and is often compromised during aging and disease.
Quiles JM +9 more
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Aging Differentially Affects Axonal Autophagosome Formation and Maturation. [PDF]
Autophagy, 2023 Misregulation of neuronal autophagy has been implicated in age-related neurodegenerative diseases including Parkinson’s disease and Huntington’s disease.
Tsong H, Holzbaur EL, Stavoe AK.
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