A novel autophagy inhibitor, bTBT, disturbs autophagosome formation [PDF]
Autophagy Reports, 2023 Macroautophagy (hereafter, autophagy) is a form of intracellular degradation in which autophagosome formation is systematically coordinated by multiple processes involving numerous autophagy-related gene (ATG) proteins. Autophagy-modulating compounds are
Momoka Chiba +6 more
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Mechanisms of autophagosome formation [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThe formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis.
Yuko FUJIOKA, Nobuo N. NODA
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Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana [PDF]
Nature Communications, 2022 Autophagosomes are specialized vesicles that target and deliver cargo to the lytic vacuole. Here the authors show that plasma-membrane derived lipid phosphatidylinositol-4-phosphate supports the assembly and expansion of autophagosomes in ...
Rodrigo Enrique Gomez +9 more
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Autophagosome formation in relation to the endoplasmic reticulum [PDF]
Journal of Biomedical Science, 2020 Autophagy is a process in which a myriad membrane structures called autophagosomes are formed de novo in a single cell, which deliver the engulfed substrates into lysosomes for degradation.
Yo-hei Yamamoto, Takeshi Noda
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Modeling Membrane Morphological Change during Autophagosome Formation [PDF]
iScience, 2020 Summary: Autophagy is an intracellular degradation process that is mediated by de novo formation of autophagosomes. Autophagosome formation involves dynamic morphological changes; a disk-shaped membrane cisterna grows, bends to become a cup-shaped ...
Yuji Sakai +4 more
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BCAS-3 is required for the progression of autophagosome formation to degrade paternal mitochondria in Caenorhabditis elegans [PDF]
iScienceSummary: In the nematode Caenorhabditis elegans, autophagy degrades paternal mitochondria after fertilization to ensure the maternal inheritance of mitochondrial DNA.
Takuya Norizuki +7 more
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SEC31a‐ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation [PDF]
Advanced ScienceAutophagy plays an important role in determining stem‐cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown.
Jiaming Nie +9 more
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Frontiers in Immunology, 2021 Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly recognized as a critical process
Ainhoa Plaza-Zabala +6 more
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Communicative & Integrative Biology, 2018 Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation.
Megha Bansal +2 more
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Does Coxsackievirus B3 Require Autophagosome Formation for Replication? Evidence for an Autophagosome-Independent Mechanism: Insights into Its Limited Potential as a Therapeutic Target [PDF]
PharmaceuticalsBackground/Objectives: Coxsackievirus B3 (CVB3), a neurotropic enterovirus, is a major causative agent of viral encephalitis and myocarditis, yet no protective vaccine or effective antiviral therapy is currently available.
Yun Ji Ga, Jung-Yong Yeh
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