Results 11 to 20 of about 5,550,027 (295)
STING recruits WIPI2 for autophagosome formation [PDF]
Autophagy, 2023 Induction of autophagy is a primordial function of the cGAS-STING pathway. However, the molecular mechanisms regulating autophagosome formation during STING-induced autophagy remain largely unknown.
Wei Wan
exaly +5 more sources
Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation [PDF]
J Cell Biol, 2023 Broadbent, Barnaba et al. analyze autophagy in living cells using HaloTagged autophagy factors to provide quantitative insight into autophagosome biogenesis, including the role of ATG2-mediated membrane tethering in the initiation of phagophores and the ...
David Broadbent +3 more
europepmc +3 more sources
ZDHHC7-mediated S -palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation [PDF]
AutophagyMacroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded.
Fujing Wei +13 more
europepmc +3 more sources
Molecular regulation of autophagosome formation. [PDF]
Biochem Soc Trans, 2022 Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative ...
Hu Y, Reggiori F, Reggiori F.
europepmc +5 more sources
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation [PDF]
Mol Cell, 2021 Summary Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by using de novo double-membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar ...
Anne Schreiber +7 more
europepmc +3 more sources
Transmembrane phospholipid translocation mediated by Atg9 is involved in autophagosome formation [PDF]
J Cell Biol, 2021 Orii et al. show that phospholipids distribute symmetrically in the yeast autophagosomal membranes. They also show that de novo–synthesized phosphatidylcholine is incorporated to autophagosomal membranes preferentially and attains the symmetrical ...
Minami Orii +3 more
europepmc +3 more sources
Structural view on autophagosome formation
FEBS Letters, 2023 Autophagy is a conserved intracellular degradation system in eukaryotes, involving the sequestration of degradation targets into autophagosomes, which are subsequently delivered to lysosomes (or vacuoles in yeasts and plants) for degradation.
N. Noda
semanticscholar +3 more sources
Membrane dynamics of ATG4B and LC3 in autophagosome formation. [PDF]
J Mol Cell Biol, 2022 The biogenesis of autophagosomes provides the basis for macroautophagy to capture and degrade intracellular cargoes. Binding of the autophagy-related protein ATG8/LC3 to autophagic membranes is essential to autophagosome formation, which involves the ...
Zhou Y +7 more
europepmc +5 more sources
Regulators of autophagosome formation in Drosophila muscles. [PDF]
PLoS Genetics, 2015 Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role of putative autophagy regulators in the specific ...
Jonathan Zirin +4 more
doaj +6 more sources
Frontiers in Immunology, 2021 Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly recognized as a critical process
Ainhoa Plaza-Zabala +6 more
doaj +2 more sources