Regulators of autophagosome formation in Drosophila muscles. [PDF]
PLoS Genetics, 2015 Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role of putative autophagy regulators in the specific ...
Jonathan Zirin +4 more
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STING recruits WIPI2 for autophagosome formation [PDF]
Autophagy, 2023 Induction of autophagy is a primordial function of the cGAS-STING pathway. However, the molecular mechanisms regulating autophagosome formation during STING-induced autophagy remain largely unknown. Recently, we reported that STING directly interacts with WIPI2 to recruit WIPI2 onto STING-positive vesicles for LC3 lipidation and autophagosome formation.
Wei Wan
exaly +4 more sources
Autophagy-related protein PlATG2 regulates the vegetative growth, sporangial cleavage, autophagosome formation, and pathogenicity of peronophythora litchii [PDF]
VirulenceAutophagy is an intracellular degradation process that is important for the development and pathogenicity of phytopathogenic fungi and for the defence response of plants.
Lin Lv +6 more
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Molecular regulation of autophagosome formation. [PDF]
Biochem Soc Trans, 2022 Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders.
Hu Y, Reggiori F, Reggiori F.
europepmc +4 more sources
The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence [PDF]
Biomolecules, 2021 Antonella Capozzi +2 more
exaly +2 more sources
Dynamics of Autophagosome Formation [PDF]
Plant Physiology, 2017 Environmental stress activates autophagy and leads to autophagosome formation at the endoplasmic reticulum.
Junmarie Soto-Burgos +3 more
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Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes [PDF]
Traffic, 2005 Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease‐containing endosomes.
Köchl, Robert +3 more
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Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation [PDF]
Molecular Biology of the Cell, 2008 Autophagy induced by nutrient depletion is involved in survival during starvation conditions. In addition to starvation-induced autophagy, the yeast Saccharomyces cerevisiae also has a constitutive autophagy-like system, the Cvt pathway. Among 31 autophagy-related (Atg) proteins, the function of Atg17, Atg29, and Atg31 is required specifically for ...
Tomoko Kawamata +4 more
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Autophagosome Formation: Tracing the Source [PDF]
Developmental Cell, 2013 Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al.
Bernard, Amélie, Klionsky, Daniel J.
openaire +2 more sources
Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. [PDF]
PLoS ONE, 2013 Mycobacterium tuberculosis is an intracellular pathogen that can survive within phagocytic cells by inhibiting phagolysosome biogenesis. However, host cells can control the intracellular M. tuberculosis burden by the induction of autophagy. The mechanism
Shintaro Seto +3 more
doaj +1 more source