A novel autophagy inhibitor, bTBT, disturbs autophagosome formation [PDF]
Autophagy Reports, 2023 Macroautophagy (hereafter, autophagy) is a form of intracellular degradation in which autophagosome formation is systematically coordinated by multiple processes involving numerous autophagy-related gene (ATG) proteins. Autophagy-modulating compounds are
Momoka Chiba +6 more
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Molecular regulation of autophagosome formation. [PDF]
Biochem Soc Trans, 2022 Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative ...
Hu Y, Reggiori F, Reggiori F.
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VAMP724 and VAMP726 are involved in autophagosome formation in Arabidopsis thaliana. [PDF]
Autophagy, 2023 Macroautophagy/autophagy, an evolutionarily conserved degradative process essential for cell homeostasis and development in eukaryotes, involves autophagosome formation and fusion with a lysosome/vacuole.
He Y +8 more
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ZDHHC7-mediated S-palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation. [PDF]
AutophagyMacroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded.
Wei F +13 more
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In situ structural analysis reveals membrane shape transitions during autophagosome formation. [PDF]
Proc Natl Acad Sci U S A, 2022 Autophagosomes are unique organelles which form de novo as double-membrane vesicles engulfing cytosolic material for destruction. Their biogenesis involves a series of membrane transformations with distinctly shaped intermediates whose ultrastructure is ...
Bieber A +10 more
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Membrane dynamics of ATG4B and LC3 in autophagosome formation. [PDF]
J Mol Cell Biol, 2022 The biogenesis of autophagosomes provides the basis for macroautophagy to capture and degrade intracellular cargoes. Binding of the autophagy-related protein ATG8/LC3 to autophagic membranes is essential to autophagosome formation, which involves the ...
Zhou Y +7 more
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Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling. [PDF]
Mil Med Res, 2022 Background Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy.
Li MZ +13 more
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Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation. [PDF]
Cell Prolif, 2023 Prevention of neointima formation is the key to improving long‐term outcomes after stenting or coronary artery bypass grafting. RNA N6‐methyladenosine (m6A) methylation has been reported to be involved in the development of various cardiovascular ...
Fang ZM +12 more
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Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. [PDF]
J Biol Chem, 2021 Macroautophagy dysregulation is implicated in multiple neurological disorders, such as Parkinson's disease. While autophagy pathways are heavily researched in heterologous cells and neurons, regulation of autophagy in the astrocyte, the most abundant ...
Pan PY +5 more
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Frontiers in Immunology, 2021 Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly recognized as a critical process
Ainhoa Plaza-Zabala +6 more
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