Results 31 to 40 of about 62,100 (242)
Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1
Signal Transduction and Targeted Therapy, 2021 Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation.
Wenchang Xiao +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 A growing body of evidence suggests that neutrophil extracellular traps (NETs) critically contribute to the development of atherosclerosis. However, the detailed mechanism of how NETs promote atherogenesis remains unknown.
Masataka Sano +8 more
doaj +1 more source
Myc inhibition impairs autophagosome formation [PDF]
Human Molecular Genetics, 2013 Autophagy, a major clearance route for many long-lived proteins and organelles, has long been implicated in cancer development. Myc is a proto-oncogene often found to be deregulated in many cancers, and thus is an attractive target for design of cancer therapy.
Toh, P.P.C. +5 more
openaire +3 more sources
PLoS Pathogens, 2022 Viruses can hijack autophagosomes as the nonlytic release vehicles in cultured host cells. However, how autophagosome-mediated viral spread occurs in infected host tissues or organs in vivo remains poorly understood.
Dongsheng Jia +7 more
doaj +1 more source
Phospholipids in Autophagosome Formation and Fusion
Journal of Molecular Biology, 2016 Autophagosomes are double membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation. Autophagosomes are formed in a de novo manner and are the result of substantial membrane remodeling processes involving numerous protein-lipid interactions.
Martens, Sascha +2 more
openaire +2 more sources
TMEM41B functions with VMP1 in autophagosome formation [PDF]
Autophagy, 2019 Macroautophagy/autophagy requires many autophagy-related (ATG) proteins. Most of the ATG genes were identified by genetic screening using simple model organisms. Recently, we performed a forward genetic screen in mammalian cells using the CRISPR-Cas9 system and our autophagic flux reporter GFP-LC3-RFP.
Keigo Morita +2 more
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Dexmedetomidine alleviates CoCl-induced hypoxic cellular damage in INS-1 cells by regulating autophagy [PDF]
Korean Journal of AnesthesiologyBackground Ischemia-reperfusion (I/R) injury is inevitable during the perioperative period. The pancreas is susceptible to I/R injury. Autophagy, a self-digestion process, is upregulated during I/R injury and strongly induced by hypoxia.
Jin Ha Park +3 more
doaj +1 more source
F1000Research, 2020 Autophagy is a conserved catabolic process critical for cell homeostasis with broad implications for aging and age-associated diseases. A defining feature of autophagy is the de novo formation of a specialized transient organelle, the double-membrane ...
Martin Graef
doaj +1 more source
Cells, 2020 Recent findings have shown that the connectivity and crosstalk between mitochondria and the endoplasmic reticulum (ER) at mitochondria–ER contact sites (MERCS) are altered in Alzheimer’s disease (AD) and in AD-related models.
Nuno Santos Leal +10 more
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Recycling endosomes contribute to autophagosome formation [PDF]
Autophagy, 2012 Autophagosome formation is a complex cellular process, which requires major membrane rearrangements leading to the creation of a relatively large double-membrane vesicle that directs its contents to the lysosome for degradation. Although various membrane compartments have been identified as sources for autophagosomal membranes, the molecular mechanism ...
Andrea, Longatti, Sharon A, Tooze
openaire +2 more sources