Results 31 to 40 of about 9,652,270 (258)
Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae [PDF]
Journal of Cell Science, 2019 Autophagy is initiated by the formation of a phagophore assembly site (PAS), the precursor of autophagosomes. In mammals, autophagosome formation sites form throughout the cytosol in specialized subdomains of the endoplasmic reticulum (ER). In yeast, the
D. Hollenstein +8 more
semanticscholar +3 more sources
Membrane closure in stress induced-autophagosome formation [PDF]
Cell Stress, 2018 Eiji Morita
doaj +2 more sources
Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy +3 more
core +5 more sources
Structural view on autophagosome formation
FEBS Letters, 2023 Autophagy is a conserved intracellular degradation system in eukaryotes, involving the sequestration of degradation targets into autophagosomes, which are subsequently delivered to lysosomes (or vacuoles in yeasts and plants) for degradation.
N. Noda
semanticscholar +1 more source
Nature Communications, 2021 Autophagy contributes to the selective degradation of liquid droplets, including the P-Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and physiological relevance of selective degradation remain unclear.
S. Kageyama +20 more
semanticscholar +1 more source
Short and long sleeping mutants reveal links between sleep and macroautophagy
eLife, 2021 Sleep is a conserved and essential behavior, but its mechanistic and functional underpinnings remain poorly defined. Through unbiased genetic screening in Drosophila, we discovered a novel short-sleep mutant we named argus.
Joseph L Bedont +7 more
doaj +1 more source
Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. [PDF]
PLoS ONE, 2013 Mycobacterium tuberculosis is an intracellular pathogen that can survive within phagocytic cells by inhibiting phagolysosome biogenesis. However, host cells can control the intracellular M. tuberculosis burden by the induction of autophagy. The mechanism
Shintaro Seto +3 more
doaj +1 more source
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation.
Molecules and Cells, 2022 ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow between tethered membranes.
A. V. van Vliet +14 more
semanticscholar +1 more source
The Function and Trafficking of Atg8 during Autophagosome Formation. [PDF]
Eukaryotic cells rely on autophagy to remove excess or damaged organelles and proteins. In this pathway, cytoplasmic materials are delivered to the lysosomes via double-membrane vesicles, the autophagosomes.
Xie, Zhiping
core +7 more sources