Results 51 to 60 of about 5,550,027 (295)

Arabidopsis NAP1 Regulates the Formation of Autophagosomes [PDF]

Current Biology, 2016
The SCAR/WAVE complex is required for ARP2/3-mediated actin nucleation, and these complexes are highly conserved in plants and animals [1, 2]. Proteins from the SCAR/WAVE complex have been found to be membrane associated in plants [3]. Using fluorescent protein fusions, we have found that NAP1 [4], a component of the SCAR/WAVE complex, locates to ...
Wang, P., Richardson, C., Hawes, C., Hussey, P.J.   +3 more
openaire   +4 more sources

Origin of the Autophagosomal Membrane in Plants

Frontiers in Plant Science, 2016
During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang, Kin Pan CHUNG, Liwen Jiang, Liwen Jiang   +3 more
doaj   +1 more source

Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1

Signal Transduction and Targeted Therapy, 2021
Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation.
Wenchang Xiao, Danna Yeerken, Jia Li, Zhangfu Li, Lanfang Jiang, Dan Li, Ming Fu, Liying Ma, Yongmei Song, Weimin Zhang, Qimin Zhan   +10 more
doaj   +1 more source

Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy

Frontiers in Cell and Developmental Biology, 2022
A growing body of evidence suggests that neutrophil extracellular traps (NETs) critically contribute to the development of atherosclerosis. However, the detailed mechanism of how NETs promote atherogenesis remains unknown.
Masataka Sano, Masataka Sano, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano   +8 more
doaj   +1 more source

Myc inhibition impairs autophagosome formation [PDF]

Human Molecular Genetics, 2013
Autophagy, a major clearance route for many long-lived proteins and organelles, has long been implicated in cancer development. Myc is a proto-oncogene often found to be deregulated in many cancers, and thus is an attractive target for design of cancer therapy.
Toh, P.P.C., Luo, S., Menzies, F.M., Raskó, T., Wanker, E.E., Rubinsztein, D.C.   +5 more
openaire   +3 more sources

A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors.

PLoS Pathogens, 2022
Viruses can hijack autophagosomes as the nonlytic release vehicles in cultured host cells. However, how autophagosome-mediated viral spread occurs in infected host tissues or organs in vivo remains poorly understood.
Dongsheng Jia, Qifu Liang, Huan Liu, Guangjun Li, Xiaofeng Zhang, Qian Chen, Aiming Wang, Taiyun Wei   +7 more
doaj   +1 more source

Phospholipids in Autophagosome Formation and Fusion

Journal of Molecular Biology, 2016
Autophagosomes are double membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation. Autophagosomes are formed in a de novo manner and are the result of substantial membrane remodeling processes involving numerous protein-lipid interactions.
Martens, Sascha, Nakamura, Shuhei, Yoshimori, Tamotsu   +2 more
openaire   +2 more sources

TMEM41B functions with VMP1 in autophagosome formation [PDF]

Autophagy, 2019
Macroautophagy/autophagy requires many autophagy-related (ATG) proteins. Most of the ATG genes were identified by genetic screening using simple model organisms. Recently, we performed a forward genetic screen in mammalian cells using the CRISPR-Cas9 system and our autophagic flux reporter GFP-LC3-RFP.
Keigo Morita, Yutaro Hama, Noboru Mizushima   +2 more
openaire   +2 more sources

Dexmedetomidine alleviates CoCl-induced hypoxic cellular damage in INS-1 cells by regulating autophagy [PDF]

Korean Journal of Anesthesiology
Background Ischemia-reperfusion (I/R) injury is inevitable during the perioperative period. The pancreas is susceptible to I/R injury. Autophagy, a self-digestion process, is upregulated during I/R injury and strongly induced by hypoxia.
Jin Ha Park, Ju Eun Oh, Namo Kim, Young-Lan Kwak   +3 more
doaj   +1 more source

Recent advances in the understanding of autophagosome biogenesis [version 1; peer review: 2 approved]

F1000Research, 2020
Autophagy is a conserved catabolic process critical for cell homeostasis with broad implications for aging and age-associated diseases. A defining feature of autophagy is the de novo formation of a specialized transient organelle, the double-membrane ...
Martin Graef
doaj   +1 more source