Results 51 to 60 of about 9,652,270 (258)
Biomolecules, 2021 Cardiolipin (CL) is a hallmark phospholipid localized within the inner mitochondrial membrane. Upon several mitochondrial stress conditions, CL is translocated to specialized platforms, where it may play a role in signaling events to promote mitophagy ...
V. Manganelli +8 more
semanticscholar +1 more source
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation [PDF]
, 2013 The membrane remodeling events required for autophagosome biogenesis are still poorly understood. Because PX domain proteins mediate membrane remodeling and trafficking, we conducted an imaging-based siRNA screen for autophagosome formation targeting ...
Søreng, Kristiane +26 more
core +1 more source
Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
, 2006 Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease-containing ...
Hu, Xiao Wen +7 more
core +4 more sources
SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease
Autophagy, 2021 Huntington disease (HD) manifests a unique macroautophagy/autophagy defect: the presense of cytosolic autophagosomes without substrates or so-called “empty” autophagosomes.
Jun-Sheng Yang, Xiaoli Chen, Huilin Xu
semanticscholar +1 more source
Autophagosome Formation: Tracing the Source [PDF]
, 2013 Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial ...
Klionsky, Daniel J., Bernard, Amélie
core +1 more source
Dexmedetomidine alleviates CoCl-induced hypoxic cellular damage in INS-1 cells by regulating autophagy [PDF]
Korean Journal of AnesthesiologyBackground Ischemia-reperfusion (I/R) injury is inevitable during the perioperative period. The pancreas is susceptible to I/R injury. Autophagy, a self-digestion process, is upregulated during I/R injury and strongly induced by hypoxia.
Jin Ha Park +3 more
doaj +1 more source
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
Nature Structural & Molecular Biology, 2020 De novo formation of the double-membrane compartment autophagosome is seeded by small vesicles carrying membrane protein autophagy-related 9 (ATG9), the function of which remains unknown.
Shintaro Maeda +9 more
semanticscholar +1 more source
F1000Research, 2020 Autophagy is a conserved catabolic process critical for cell homeostasis with broad implications for aging and age-associated diseases. A defining feature of autophagy is the de novo formation of a specialized transient organelle, the double-membrane ...
Martin Graef
doaj +1 more source
Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae [PDF]
, 2007 Autophagy is a degradation process accompanied by dynamic membrane organization. In the yeast, Saccharomyces cerevisiae, about 30 ATG (autophagy-related) genes have been identified as important genes for autophagy.
Ohsumi, Yoshinori, Suzuki, Kuninori
core +1 more source
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion
Autophagy, 2022 SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy.
Hong Huang +6 more
semanticscholar +1 more source