Results 91 to 100 of about 286,383 (199)

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

Induction of Autophagy Causes Dramatic Changes in the Subcellular Distribution of GFP‐Rab24 [PDF]

, 2002
Daniela B. Munafó, María Isabel Colombo   +1 more
openalex   +1 more source

Potential of autophagy in subretinal fibrosis in neovascular age-related macular degeneration. [PDF]

Cell Mol Biol Lett
Blasiak J, Pawlowska E, Helotera H, Ionov M, Derwich M, Kaarniranta K.   +5 more
europepmc   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor [PDF]

, 2002
Ana María Cuervo
openalex   +1 more source

Autophagy Regulates Putative Anion Transporter 1 Expression in Intestinal Epithelial Cells. [PDF]

J Cell Mol Med
Priyamvada S, Jayawardena D, Anbazhagan AN, Kumar A, Saksena S, Gill RK, Borthakur A, Alrefai WA, Dudeja PK.   +8 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Autophagy lurks around lurcher [PDF]

, 2002
Juan Carlos López
openalex   +1 more source

Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma. [PDF]

Discov Oncol
Michetti F, Cirone M, Strippoli R, D'Orazi G, Cordani M.   +4 more
europepmc   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source