Harnessing autophagy to overcome mitogen‐activated protein kinase kinase inhibitor‐induced resistance in metastatic melanoma [PDF]
, 2019 Background Patients with malignant melanoma often relapse after treatment with BRAF and/or mitogen‐activated protein kinase kinase (MEK) inhibitors (MEKi) owing to development of drug resistance.
Alexander, M. +6 more
core +1 more source
Facets of Autophagy Based Unconventional Protein Secretion–The Road Less Traveled
Frontiers in Molecular Biosciences, 2020 Unconventional protein secretion (UCPS) of leaderless proteins bypasses the conventional endoplasmic reticulum (ER)-Golgi route. The proportion of UCPS in the secretome varies tremendously across eukaryotes.
Sreedevi Padmanabhan +2 more
doaj +1 more source
HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
core +1 more source
Regulation of anti-microbial autophagy by factors of the complement system
Microbial Cell, 2020 The complement system is a major component of innate immunity that participates in the defense of the host against a myriad of pathogenic microorganisms.
Christophe Viret +5 more
doaj +1 more source
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]
, 2015 Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena +10 more
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FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]
, 2019 The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine +9 more
core +1 more source
WIPI-Mediated Autophagy and Longevity
Cells, 2015 Autophagy is a lysosomal degradation process for cytoplasmic components, including organelles, membranes, and proteins, and critically secures eukaryotic cellular homeostasis and survival.
Mona Grimmel +2 more
doaj +1 more source
Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice [PDF]
, 2017 Autophagy is usually a pro-survival mechanism in cancer cells, especially in the course of chemotherapy, thus autophagy inhibition may enhance the chemotherapy-mediated anti-cancer effect.
Bei, R. +10 more
core +1 more source
Obstetrics & Gynecology Science, 2017 Autophagy is an evolutionarily conserved catalytic process by which cytoplasmic components including damaged macromolecules and organelles are degraded. The role of autophagy includes adaptive responses to nutrition deprivation or intracellular stimuli.
Soo-young Oh, Cheong-Rae Roh
openaire +3 more sources
Cellular & Molecular Biology LettersBackground Systemic lupus erythematosus (SLE), influenced by gut microbiota dysbiosis, is characterized by autoimmune and inflammatory responses. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation is an effective and safe ...
Quanren Pan +13 more
doaj +1 more source