Results 71 to 80 of about 373,644 (316)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Autophagy in Tuberculosis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Autophagy as an immune mechanism controls inflammation and acts as a cell-autonomous defense against intracellular microbes including Mycobacterium tuberculosis. An equally significant role of autophagy is its anti-inflammatory and tissue-sparing function. This combination of antimicrobial and anti-inflammatory actions prevents active disease in animal
openaire   +2 more sources

Phosphatidylethanolamine positively regulates autophagy and longevity

, 2015
This work was supported by the Austrian Science Fund FWF (grants LIPOTOX, I1000-B20, P23490-B12, and P24381-B20) to FM. The authors acknowledge support from NAWI Graz.
Pietrocola, F., Knittelfelder, O., O Knittelfelder, Franz, J, Pietrocola, F, Rockenfeller, Patrick, Carmona-Gutierrez, D., Madeo, F., Minois, N, Knittelfelder, O, J Franz, M Koska, Franz, J., Carmona-Gutierrez, D, G Kroemer, Madeo, F, Koska, M., Minois, N., Sica, V., Kroemer, G., F Pietrocola, Koska, M, D Carmona-Gutierrez, Kroemer, G, Rockenfeller, P, V Sica, F Madeo, N Minois, Rockenfeller, P., Sica, V, P Rockenfeller   +30 more
core   +1 more source

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila [PDF]

, 2008
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3)) – kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear.
Backer, J. M., Baehrecke, EH, Miklós Sass, Hill, JH, Ying Yan, Hill, J. H., Sass, Miklós, Jahda H. Hill, Backer, JM, Gábor Juhász, Thomas P. Neufeld, Jonathan M. Backer, Baehrecke, E. H., Yan, Y, Neufeld, TP, Juhász, Gábor, Yan, Y., Neufeld, T. P., Eric H. Baehrecke   +18 more
core   +1 more source

WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation

EMBO Reports
One of the key events in autophagy is the formation of a double-membrane phagophore, and many regulatory mechanisms underpinning this remain under investigation.
Andrea Gubas, Eleanor Attridge, Harold BJ Jefferies, Taki Nishimura, Minoo Razi, Simone Kunzelmann, Yuval Gilad, Thomas J Mercer, Michael M Wilson, Adi Kimchi, Sharon A Tooze   +10 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Autophagy and cancer

World Journal of Biological Chemistry, 2013
Autophagy is a homeostatic and evolutionarily conserved mechanism of self-digestion by which the cells degrade and recycle long-lived proteins and excess or damaged organelles. Autophagy is activated in response to both physiological and pathological stimuli including growth factor depletion, energy deficiency or the upregulation of Bcl-2 protein ...
Si-Zhao, Lu, Duygu Dee, Harrison-Findik
openaire   +2 more sources

Selenium nanoparticles alleviate renal ischemia/reperfusion injury by inhibiting ferritinophagy via the XBP1/NCOA4 pathway

Cell Communication and Signaling
Acute kidney injury (AKI) is closely related to lysosomal dysfunction and ferroptosis in renal tubular epithelial cells (TECs), for which effective treatments are urgently needed.
Zhenying Zuo, Mianna Luo, Zhongyu Liu, Ting Liu, Xi Wang, Xiaorong Huang, Shangmei Li, Hongluan Wu, Qingjun Pan, Tianfeng Chen, Lawei Yang, Hua-Feng Liu   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Synthesis and screening of 3-MA derivatives for autophagy inhibitors

, 2013
Autophagy is a conserved degradation process, which plays important pathophysiological roles. The lack of effective inhibitors of autophagy has been an obstacle in both basic research and understanding the physiological role of autophagy in disease ...
Li Yu, Zhang, Xiao-Bo, Shi, Zhang-Jie, Wang, Xin, Xiao-Bo Zhang, Yu, Li, Xin Wang, Zhang-Jie Shi, Zhang, Bo, Guo, Haijing, Bo Zhang, Yanyang Wu, Haijing Guo, Wu, Yanyang   +13 more
core   +1 more source