Results 61 to 70 of about 401,976 (308)

Autophagy and cancer

World Journal of Biological Chemistry, 2013
Autophagy is a homeostatic and evolutionarily conserved mechanism of self-digestion by which the cells degrade and recycle long-lived proteins and excess or damaged organelles. Autophagy is activated in response to both physiological and pathological stimuli including growth factor depletion, energy deficiency or the upregulation of Bcl-2 protein ...
Si-Zhao, Lu, Duygu Dee, Harrison-Findik
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Autophagy and Noroviruses [PDF]

Viruses, 2019
Autophagy is an essential cellular process by which a cell degrades materials within its cytoplasm. Intracellular pathogens like viruses must deal with autophagy, either positively or negatively, for their own survival and replication. For some viruses, autophagy can even play proviral roles, helping their replication or dissemination.
Kevin Furlong, Seungmin Hwang
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and autoimmunity [PDF]

Clinical Immunology, 2017
Autophagy is a highly conserved protein degradation pathway from yeasts to humans that is essential for removing protein aggregates and misfolded proteins in healthy cells. Recently, autophagy-related genes polymorphisms have been implicated in several autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and ...
Wu, Dennis J, Adamopoulos, Iannis E
openaire   +4 more sources

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling [PDF]

, 2009
BackgroundMammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Trevor C F Tsang, Roberge, Michel, Bruno D Fonseca, Patrick Lajoie, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Aruna D Balgi, Michel Roberge, Tsang Trevor C. F., Ivan R Nabi, Lajoie, P., Nabi Ivan R., Fonseca, B., Balgi, Aruna D., Fonseca, Bruno D., Proud, C., Tsang, T., Balgi, A., Nabi, Ivan R., Roberge, M., Balgi Aruna D., Proud Christopher G., Lajoie Patrick, Roberge Michel, Donohue, Elizabeth, Christopher G Proud, Donohue Elizabeth, Nabi, I., Fonseca Bruno D., Donohue, E., Elizabeth Donohue   +31 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Viruses and autophagy [PDF]

Reviews in Medical Virology, 2009
AbstractAutophagy is an evolutionarily conserved intracellular process by which bulk cytoplasm is enveloped inside a double‐membraned vesicle and shuttled to lysosomes for degradation. Within the last 15 years, the genes necessary for the execution of autophagy have been identified and the number of tools for studying this process has grown.
Sagar B, Kudchodkar, Beth, Levine
openaire   +2 more sources

Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors [PDF]

, 2011
Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagylysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to ...
Sirko, Agnieszka, Jolanta Łukomska, Surowiecki, Przemysław, Agnieszka Sirko, Lewandowska, Małgorzata, Liszewska, Frantz, Małgorzata Lewandowska, Anna Wawrzyńska, Grzegorz Moniuszko, Łukomska, Jolanta, Frantz Liszewska, Moniuszko, Grzegorz, Wawrzyńska, Anna, Gwozdecki, Rafał, Katarzyna Zientara-Rytter, Rafał Gwozdecki, Przemysław Surowiecki, Zientara-Rytter, Katarzyna   +17 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source