Results 61 to 70 of about 373,644 (316)

Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors [PDF]

, 2011
Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagylysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to ...
Sirko, Agnieszka, Jolanta Łukomska, Surowiecki, Przemysław, Agnieszka Sirko, Lewandowska, Małgorzata, Liszewska, Frantz, Małgorzata Lewandowska, Anna Wawrzyńska, Grzegorz Moniuszko, Łukomska, Jolanta, Frantz Liszewska, Moniuszko, Grzegorz, Wawrzyńska, Anna, Gwozdecki, Rafał, Katarzyna Zientara-Rytter, Rafał Gwozdecki, Przemysław Surowiecki, Zientara-Rytter, Katarzyna   +17 more
core   +1 more source

The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines

Bio-Protocol, 2018
Autophagy is a key player in the maintenance of cellular homeostasis in eukaryotes, and numerous diseases, including cancer and neurodegenerative disorders, are associated with alterations in autophagy.
Morten Luhr, Frank Sætre, Nikolai Engedal   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Autophagy in Dementias

Brain Pathology, 2011
AbstractDementias are a varied group of disorders typically associated with memory loss, impaired judgment and/or language and by symptoms affecting other cognitive and social abilities to a degree that interferes with daily functioning. Alzheimer's disease (AD) is the most common cause of a progressive dementia, followed by dementia with Lewy bodies ...
Christine Lund, Kragh, Kiren, Ubhi, Tony, Wyss-Coray, Tony, Wyss-Corey, Eliezer, Masliah   +4 more
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Autophagy: A Forty-Year Search for a Missing Membrane Source

, 2006
Autophagy is the major self-degradative process in eukaryotic cells, with fundamental roles in cellular and organismal homeostasis, and is involved in many developmental and pathological situations.
Juhasz Gabor, Neufeld, Thomas P., Neufeld Thomas P, Gabor Juhasz, Juhász, Gábor, Thomas P Neufeld   +5 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

, 2013
The authors acknowledge TENOVUS Tayside for funding the studyTenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-
Coates, Philip J., Groves, M.J., Prescott, A.R., Nicolaou, A., Murray, Karen, Ganley, Ian G.; id_orcid, Lain, S., Tauro, S., Haydock, S., Appleyard, V., Ganley, I.G., James, John, Nicolaou, Anna; id_orcid, Cunningham, Joan, Cunningham, J., Tauro, Sudhir, Murray, K., Prescott, Alan R., Drbal, Abed Alnaser A.A., Coates, P.J., James, J., MacCallum, S., Lain, Sonia, Drbal, A.A., MacCallum, Stephanie F., Drbal, Abed A., Haydock, Sally, Westwood, N.J., Prescott, Alan R.; id_orcid, Ganley, Ian G., Groves, Michael J., Nicolaou, Anna, Westwood, Nicholas J., Appleyard, Virginia   +33 more
core   +1 more source

Early endosomes and endosomal coatomer are required for autophagy [PDF]

, 2009
Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal ...
Edmond Y.W. Chan, Tooze, Sharon A., Sharon A. Tooze, Chan, Edmond Y., Razi, M., Minoo Razi   +5 more
core   +1 more source

Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP

iScience
Summary: Among its various functions, the sigma-1 receptor (σ1R) has been reported to modulate macroautophagy. It is currently unknown how this activity is mediated. We phylogenetically, structurally, and biochemically analyzed σ1R regarding its function
Marius Wilhelm Baeken, Maximilian Christ, Daniel Schmitt, Wencke Trein, Heike Nagel, Albrecht Martin Clement, Hagen Körschgen, Christian Behl   +7 more
doaj   +1 more source