Results 51 to 60 of about 401,976 (308)

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2013
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Coombs, G.H., Williams, Roderick A M, Mottram, Jeremy C, Williams, R.A.M, Coombs, Graham H, Mottram, J.C., Jeremy C. Mottram, Graham H. Coombs, Roderick A.M. Williams   +8 more
core   +1 more source

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

Nature Communications, 2020
Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö, Jonathan Lucien Stahl, Elena Favaro, Qing Yang, Bin Liu, Line Christoffersen, Ben Loos, Claudia Guasch Boldú, Johanna A. Joyce, Thomas Reinheckel, Marin Barisic, Marja Jäättelä   +11 more
doaj   +1 more source

The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson’s disease is promoted by conserved oxidation sites

Cell Death Discovery, 2021
The sirtuin (SIRT) protein family has been of major research interest over the last decades because of their involvement in aging, cancer, and cell death.
Marius W. Baeken, Mario Schwarz, Andreas Kern, Bernd Moosmann, Parvana Hajieva, Christian Behl   +5 more
doaj   +1 more source

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Platt, A., MAIURI, MARIA CHIARA, CARNUCCIO, ROSA, Maffia, P., Gianluca Grassia, Armando Ialenti, Ialenti, A., GRASSIA, GIANLUCA, Carnuccio, R., Maria Chiara Maiuri, MAFFIA, PASQUALE, IALENTI, ARMANDO, Grassia, G., Pasquale Maffia, Maiuri, M.C., Andrew M. Platt, Rosa Carnuccio   +16 more
core   +1 more source

Autophagy in Tuberculosis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Autophagy as an immune mechanism controls inflammation and acts as a cell-autonomous defense against intracellular microbes including Mycobacterium tuberculosis. An equally significant role of autophagy is its anti-inflammatory and tissue-sparing function. This combination of antimicrobial and anti-inflammatory actions prevents active disease in animal
openaire   +2 more sources

Autophagy and tumorigenesis [PDF]

FEBS Letters, 2009
Autophagy, or cellular self‐digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Nonetheless, genetic evidence supports that autophagy functions as a tumor suppressor mechanism.
Chen, Nan, Debnath, Jayanta
openaire   +2 more sources

Elastase induces lung epithelial cell autophagy through placental growth factor A new insight of emphysema pathogenesis

, 2017
Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated with increasing mortality and morbidity. Therefore, there is a need to clearly define the COPD pathogenic mechanism and to explore effective therapies.
Hou, Hsin-Han;Cheng, Shih-Lung;Chung, Kuei-Pin;Kuo, Mark Yen-Ping;Yeh, Cheng-Chang;Chang, Bei-En;Lu, Hsuan-Hsuan;Wang, Hao-Chien;Yu, Chong-Jen, 王鶴健;張百恩;余忠仁;郭彥彬;鐘桂彬   +1 more
core   +1 more source

Autophagy in Cancer Immunotherapy

, 2022
Autophagy is a stress-induced process that eliminates damaged organelles and dysfunctional cargos in cytoplasm, including unfolded proteins. Autophagy is involved in constructing the immunosuppressive microenvironment during tumor initiation and ...
Yuhe Lei, Bai, Liangliang, Yingjie Li, Lei, Yuhe, Liangliang Bai, Zhang, Enxin, Enxin Zhang, Li, Yingjie   +7 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines

Bio-Protocol, 2018
Autophagy is a key player in the maintenance of cellular homeostasis in eukaryotes, and numerous diseases, including cancer and neurodegenerative disorders, are associated with alterations in autophagy.
Morten Luhr, Frank Sætre, Nikolai Engedal   +2 more
doaj   +1 more source