Results 51 to 60 of about 415,735 (308)
Cell Death Discovery, 2021 The sirtuin (SIRT) protein family has been of major research interest over the last decades because of their involvement in aging, cancer, and cell death.
Marius W. Baeken +5 more
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Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate Immunity
, 2023 Crohn’s disease (CD) is a chronic inflammatory bowel disease marked by relapsing, transmural intestinal inflammation driven by innate and adaptive immune responses.
Arianne L. Theiss, Kibrom M. Alula
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Brain Pathology, 2011 AbstractDementias are a varied group of disorders typically associated with memory loss, impaired judgment and/or language and by symptoms affecting other cognitive and social abilities to a degree that interferes with daily functioning. Alzheimer's disease (AD) is the most common cause of a progressive dementia, followed by dementia with Lewy bodies ...
Christine Lund, Kragh +4 more
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Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
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Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors [PDF]
, 2011 Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagylysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to ...
Sirko, Agnieszka +17 more
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Autophagy in Cancer Immunotherapy
, 2022 Autophagy is a stress-induced process that eliminates damaged organelles and dysfunctional cargos in cytoplasm, including unfolded proteins. Autophagy is involved in constructing the immunosuppressive microenvironment during tumor initiation and ...
Yuhe Lei +7 more
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Cells, 2012 Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks ...
Vincenzo Giansanti +3 more
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Bio-Protocol, 2018 Autophagy is a key player in the maintenance of cellular homeostasis in eukaryotes, and numerous diseases, including cancer and neurodegenerative disorders, are associated with alterations in autophagy.
Morten Luhr +2 more
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Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]
, 2013 Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Coombs, G.H. +8 more
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Autophagy in Tuberculosis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Autophagy as an immune mechanism controls inflammation and acts as a cell-autonomous defense against intracellular microbes including Mycobacterium tuberculosis. An equally significant role of autophagy is its anti-inflammatory and tissue-sparing function. This combination of antimicrobial and anti-inflammatory actions prevents active disease in animal
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