Results 31 to 40 of about 373,644 (316)
Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
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Cell Death Discovery, 2022 Acute kidney injury (AKI) is a common clinical condition associated with high morbidity and mortality. The pathogenesis of AKI has not been fully elucidated, with a lack of effective treatment. Renal tubular epithelial cells (TECs) play an important role
Zixian Li +9 more
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Experimental Control and Characterization of Autophagy in Drosophila [PDF]
, 2008 Insects such as the fruit fly Drosophila melanogaster, which fundamentally reorganize their body plan during metamorphosis, make extensive use of autophagy for their normal development and physiology.
Thomas P. Neufeld +3 more
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ACS Chemical Neuroscience, 2014 Lithium, a drug used to treat bipolar disorders, has a variety of neuroprotective mechanisms, including autophagy regulation, in various neuropsychiatric conditions. In neurodegenerative diseases, lithium enhances degradation of aggregate-prone proteins, including mutated huntingtin, phosphorylated tau, and α-synuclein, and causes damaged mitochondria ...
Yumiko, Motoi +3 more
openaire +2 more sources
Nature Communications, 2019 Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth +8 more
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Plasma membrane integrity in health and disease: significance and therapeutic potential
Cell Discovery, 2021 Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
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The Role of Autophagy in Pancreatic Cancer—Recent Advances
Biology, 2019 Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with a 5-year survival rate of only 9%, despite ongoing efforts to improve treatment.
Maria New, Sharon Tooze
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Autophagy, selective autophagy, and necroptosis in COPD
International Journal of Chronic Obstructive Pulmonary Disease, 2018 COPD is characterized by persistent respiratory symptoms and airflow limitation, caused by a mixture of small airway disease and pulmonary emphysema. Programmed cell death has drawn the attention of COPD researchers because emphysema is thought to result from epithelial cell death caused by smoking.
Kenji Mizumura +3 more
openaire +5 more sources
Time flies : autophagy during ageing in Drosophila [PDF]
, 2013 The process of ageing compromises the age-associated decrease in fertility, gradual loss of function, and increased vulnerability to disease, which progressively diminishes the capability of an organism to survive [1-3]. Unsurprisingly, in the past years
Nezis, I. P. +5 more
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Emerging roles of TFE3 in metabolic regulation
Cell Death Discovery, 2023 TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic ...
Xingyu Li +6 more
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