Results 21 to 30 of about 401,976 (308)
Early endosomes and endosomal coatomer are required for autophagy [PDF]
, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal ...
Tooze, Sharon A. +2 more
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Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells [PDF]
Middle East Journal of Cancer, 2021 Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3.
Hamid Behrouj +3 more
doaj +1 more source
The selectivity and specificity of autophagy in drosophila [PDF]
, 2012 Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Nezis, I. P., Ioannis P. Nezis
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ERMP1 Facilitates The Malignant Characteristics of Colorectal Cancer Cells through Modulating PI3K/AKT/β-Catenin Pathway and Localization of GRP78 [PDF]
Cell Journal, 2023 Objective: Endoplasmic reticulum-metallopeptidase 1 (ERMP1) is involved in cellular response to oxidative stress.However, its functional role in proliferation and progression of cancer cells remains unknown.
Nasim Rahmani-Kukia +2 more
doaj +1 more source
Frontiers in Endocrinology, 2019 Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM).
María Paz Hernández-Cáceres +28 more
doaj +1 more source
Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
doaj +1 more source
Cutting a fine figure : On the use of thin sections in electron microscopy to quantify autophagy [PDF]
, 2013 Over the last few years, two guideline articles have been published with recommendations for assessing autophagy. These articles contained advice on quantification of autophagy by electron microscopy and proposed using thin slices for quantifying ...
Hacker, Christian, Lucocq, John Milton
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Receptor proteins in selective autophagy [PDF]
, 2012 Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Simone Fulda +3 more
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Autophagy, selective autophagy, and necroptosis in COPD
International Journal of Chronic Obstructive Pulmonary Disease, 2018 COPD is characterized by persistent respiratory symptoms and airflow limitation, caused by a mixture of small airway disease and pulmonary emphysema. Programmed cell death has drawn the attention of COPD researchers because emphysema is thought to result from epithelial cell death caused by smoking.
Kenji Mizumura +3 more
openaire +5 more sources
Autophagy in Drosophila : from historical studies to current knowledge [PDF]
, 2014 The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field, and made it possible to carry out functional studies in model organisms.
Nezis, I. P. +13 more
core +1 more source