Results 21 to 30 of about 373,644 (316)
Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Proto, William R. +7 more
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Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells [PDF]
Middle East Journal of Cancer, 2021 Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3.
Hamid Behrouj +3 more
doaj +1 more source
Current Biology, 2019 In 1955, the biologist and Nobel Prize laureate Christian de Duve discovered that cells possess specialized organelles filled with hydrolytic enzymes and he called these organelles lysosomes. At the same time, electron microscopy studies by Novikoff and colleagues showed that intracellular dense bodies, which later turned out to be lysosomes, contain ...
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Cancer Science, 2021 AbstractWhile starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins ...
Mohammad Omar Faruk +2 more
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ERMP1 Facilitates The Malignant Characteristics of Colorectal Cancer Cells through Modulating PI3K/AKT/β-Catenin Pathway and Localization of GRP78 [PDF]
Cell Journal, 2023 Objective: Endoplasmic reticulum-metallopeptidase 1 (ERMP1) is involved in cellular response to oxidative stress.However, its functional role in proliferation and progression of cancer cells remains unknown.
Nasim Rahmani-Kukia +2 more
doaj +1 more source
Frontiers in Endocrinology, 2019 Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM).
María Paz Hernández-Cáceres +28 more
doaj +1 more source
Cell, 2011 Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition ...
Rubinsztein, David C. +2 more
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Receptor proteins in selective autophagy [PDF]
, 2012 Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Simone Fulda +3 more
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Autophagy in Drosophila : from historical studies to current knowledge [PDF]
, 2014 The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field, and made it possible to carry out functional studies in model organisms.
Nezis, I. P. +13 more
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MIR376A is a regulator of starvation-induced autophagy [PDF]
, 2013 Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Gozuacik Devrim +25 more
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