Results 11 to 20 of about 373,644 (316)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) [PDF]
, 2022 Funding: This work was supported by the National Institute of General Medical Sciences [GM131919].In 2008, we published the first set of guidelines for standardizing research in autophagy.
Autophagy Group +2 more
core +2 more sources
Autophagy and Autophagy-Related Diseases: A Review [PDF]
International Journal of Molecular Sciences, 2020 Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells.
Tadashi Ichimiya +8 more
openaire +2 more sources
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Molecular Medicine, 2023 AbstractAutophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for degradation and elimination. The mechanistic target of rapamycin (mTOR) is the main negative regulator of autophagy.
Naif H. Ali +7 more
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Autophagy and autophagy-related proteins in cancer [PDF]
Molecular Cancer, 2020 AbstractAutophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins and their core complexes including ULK1/2 kinase core complex, autophagy-specific class III ...
Xiaohua Li, Shikun He, Binyun Ma
openaire +3 more sources
Autophagy in Trypanosomatids [PDF]
Cells, 2012 Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, although with low sequence ...
Brennand, A. +2 more
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Autophagy-Independent Functions of the Autophagy Machinery [PDF]
Cell, 2019 Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that
Galluzzi, Lorenzo, Green, Douglas R.
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Autophagy-monitoring and autophagy-deficient mice [PDF]
Autophagy, 2017 Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ...
Akiko Kuma +2 more
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Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns
Frontiers in Cell and Developmental Biology, 2022 Macroautophagy (henceforth autophagy) an evolutionary conserved intracellular pathway, involves lysosomal degradation of damaged and superfluous cytosolic contents to maintain cellular homeostasis.
Cuckoo Teresa Jetto +3 more
doaj +1 more source
The selectivity and specificity of autophagy in drosophila [PDF]
, 2012 Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Nezis, I. P., Ioannis P. Nezis
core +1 more source
Nature Medicine, 2010 Susceptibility to Crohn's disease has been linked to polymorphisms in genes involved in two pathophysiological pathways: autophagy and the recognition of bacterial peptidoglycan by nucleotide oligomerization domain-2 (NOD2), an intracellular receptor.
Netea, M.G., Joosten, L.A.B.
openaire +2 more sources