Results 11 to 20 of about 415,735 (308)
Autophagy, selective autophagy, and necroptosis in COPD
International Journal of Chronic Obstructive Pulmonary Disease, 2018 Kenji Mizumura, Shuichiro Maruoka, Tetsuo Shimizu, Yasuhiro Gon Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan Abstract: COPD is characterized by persistent respiratory symptoms and ...
Maruoka S, Gon Y, Shimizu T, Mizumura K
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) [PDF]
, 2022 Funding: This work was supported by the National Institute of General Medical Sciences [GM131919].In 2008, we published the first set of guidelines for standardizing research in autophagy.
Autophagy Group +2 more
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Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy +3 more
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Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Molecular Medicine, 2023 AbstractAutophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for degradation and elimination. The mechanistic target of rapamycin (mTOR) is the main negative regulator of autophagy.
Naif H. Ali +7 more
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Autophagy and Autophagy-Related Diseases: A Review [PDF]
International Journal of Molecular Sciences, 2020 Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells.
Tadashi Ichimiya +8 more
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Autophagy and autophagy-related proteins in cancer [PDF]
Molecular Cancer, 2020 AbstractAutophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins and their core complexes including ULK1/2 kinase core complex, autophagy-specific class III ...
Xiaohua Li, Shikun He, Binyun Ma
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Cancer Science, 2021 AbstractWhile starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins ...
Mohammad Omar Faruk +2 more
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Autophagy-monitoring and autophagy-deficient mice [PDF]
Autophagy, 2017 Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ...
Akiko Kuma +2 more
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Autophagy-Independent Functions of the Autophagy Machinery [PDF]
Cell, 2019 Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that
Galluzzi, Lorenzo, Green, Douglas R.
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Early endosomes and endosomal coatomer are required for autophagy [PDF]
, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal ...
Tooze, Sharon A. +2 more
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