Results 11 to 20 of about 517,228 (307)
Cancer Science, 2021 AbstractWhile starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins ...
Mohammad Omar Faruk +2 more
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Journal of Immunology Research, 2023 Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment
Hui-Yuan Li +8 more
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hUC-MSC transplantation therapy effects on lupus-prone MRL/lpr mice at early disease stages
Stem Cell Research & Therapy, 2023 Background The efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials.
Fengbiao Guo +13 more
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The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
Autophagy Reports, 2023 Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health.
Anne Kristin McLaren Berge +3 more
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Cell Death and Disease, 2022 Cancer genomics and cancer mutation databases have made an available wealth of information about missense mutations found in cancer patient samples. Contextualizing by means of annotation and predicting the effect of amino acid change help identify which
Matteo Tiberti +6 more
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Cells, 2022 Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde +9 more
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Cells, 2022 The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated.
Jonathan Stahl-Meyer +4 more
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Current Biology, 2019 In 1955, the biologist and Nobel Prize laureate Christian de Duve discovered that cells possess specialized organelles filled with hydrolytic enzymes and he called these organelles lysosomes. At the same time, electron microscopy studies by Novikoff and colleagues showed that intracellular dense bodies, which later turned out to be lysosomes, contain ...
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Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology, 2020 Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert +17 more
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Unraveling membrane properties at the organelle-level with LipidDyn
Computational and Structural Biotechnology Journal, 2022 Cellular membranes are formed from different lipids in various amounts and proportions depending on the subcellular localization. The lipid composition of membranes is sensitive to changes in the cellular environment, and its alterations are linked to ...
Simone Scrima +11 more
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