Results 41 to 50 of about 401,976 (308)

Annexins: players of single cell wound healing and regeneration

Communicative & Integrative Biology, 2019
Cell life is defined by a thin 4 nm plasma membrane, which separates the interior of a cell from its environment. Thus, disruption of the plasma membrane poses a critical risk to cells, which requires immediate repair to avoid uncontrolled osmotic lysis ...
Swantje Christin Häger, Jesper Nylandsted   +1 more
doaj   +1 more source

Autophagy in Platelets [PDF]

, 2019
Anucleate platelets are produced by fragmentation of megakaryocytes. Platelets circulate in the bloodstream for a finite period: upon vessel injury, they are activated to participate in hemostasis; upon senescence, unused platelets are cleared. Platelet hypofunction leads to bleeding. Conversely, pathogenic platelet activation leads to occlusive events
Meenakshi, Banerjee, Yunjie, Huang, Madhu M, Ouseph, Smita, Joshi, Irina, Pokrovskaya, Brian, Storrie, Jinchao, Zhang, Sidney W, Whiteheart, Qing Jun, Wang   +8 more
openaire   +2 more sources

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 [PDF]

, 2013
The authors acknowledge TENOVUS Tayside for funding the studyTenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-
Coates, Philip J., Groves, M.J., Prescott, A.R., Nicolaou, A., Murray, Karen, Ganley, Ian G.; id_orcid, Lain, S., Tauro, S., Haydock, S., Appleyard, V., Ganley, I.G., James, John, Nicolaou, Anna; id_orcid, Cunningham, Joan, Cunningham, J., Tauro, Sudhir, Murray, K., Prescott, Alan R., Drbal, Abed Alnaser A.A., Coates, P.J., James, J., MacCallum, S., Lain, Sonia, Drbal, A.A., MacCallum, Stephanie F., Drbal, Abed A., Haydock, Sally, Westwood, N.J., Prescott, Alan R.; id_orcid, Ganley, Ian G., Groves, Michael J., Nicolaou, Anna, Westwood, Nicholas J., Appleyard, Virginia, Prescott, AR, Murray, K, Nicolaou, A, Haydock, S, Drbal, AA, Cunningham, J, Appleyard, V, James, J, MacCallum, SF, Groves, MJ   +43 more
core   +1 more source

Emerging roles of TFE3 in metabolic regulation

Cell Death Discovery, 2023
TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic ...
Xingyu Li, Yongming Chen, Siqiao Gong, Huixia Chen, Huafeng Liu, Xiaoyu Li, Junfeng Hao   +6 more
doaj   +1 more source

Phosphatidylethanolamine positively regulates autophagy and longevity [PDF]

, 2015
This work was supported by the Austrian Science Fund FWF (grants LIPOTOX, I1000-B20, P23490-B12, and P24381-B20) to FM. The authors acknowledge support from NAWI Graz.
Pietrocola, F., Knittelfelder, O., O Knittelfelder, Franz, J, Pietrocola, F, Rockenfeller, Patrick, Carmona-Gutierrez, D., Madeo, F., Minois, N, Knittelfelder, O, J Franz, M Koska, Franz, J., Carmona-Gutierrez, D, G Kroemer, Madeo, F, Koska, M., Minois, N., Sica, V., Kroemer, G., F Pietrocola, Koska, M, D Carmona-Gutierrez, Kroemer, G, Rockenfeller, P, V Sica, F Madeo, N Minois, Rockenfeller, P., Sica, V, P Rockenfeller   +30 more
core   +1 more source

Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion

Cells, 2020
Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way to prevent disease progression in these patients.
Ditte Marie Brix, Knut Kristoffer Bundgaard Clemmensen, Tuula Kallunki   +2 more
doaj   +1 more source

Atg8ylation as a general membrane stress and remodeling response

Cell Stress, 2021
The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
doaj   +1 more source

Time flies : autophagy during ageing in Drosophila [PDF]

, 2013
The process of ageing compromises the age-associated decrease in fertility, gradual loss of function, and increased vulnerability to disease, which progressively diminishes the capability of an organism to survive [1-3]. Unsurprisingly, in the past years
Nezis, I. P., Andreas Brech, Brech, Andreas, Shultz, Sebastian Wolfgang, Ioannis P., Sebastian Wolfgang   +5 more
core   +1 more source

Autophagy at the synapse [PDF]

Neuroscience Letters, 2019
As the sites of communication between neurons, synapses depend upon precisely regulated protein-protein interactions to support neurotransmitter release and reception. Moreover, neuronal synapses typically exist great distances (i.e. up to meters) away from cell bodies, which are the sources of new proteins and the major sites of protein degradation ...
Veronica Birdsall, Clarissa L. Waites
openaire   +2 more sources

Autophagy in Dementias

Brain Pathology, 2011
AbstractDementias are a varied group of disorders typically associated with memory loss, impaired judgment and/or language and by symptoms affecting other cognitive and social abilities to a degree that interferes with daily functioning. Alzheimer's disease (AD) is the most common cause of a progressive dementia, followed by dementia with Lewy bodies ...
Christine Lund, Kragh, Kiren, Ubhi, Tony, Wyss-Coray, Tony, Wyss-Corey, Eliezer, Masliah   +4 more
openaire   +3 more sources