Results 41 to 50 of about 373,644 (316)
Autophagy, 2012 The microenvironment of solid tumors tends to be more acidic (6.5-7.0) than surrounding normal (7.2-7.4) tissue. Chaotic vasculature, oxygen limitation and major metabolic changes all contribute to the acidic microenvironment. We have previously proposed that low extracellular pH (pHe) plays a critical role in the development and progression of solid ...
Jonathan W, Wojtkowiak +1 more
openaire +2 more sources
Autophagy in Cancer Immunotherapy
, 2022 Autophagy is a stress-induced process that eliminates damaged organelles and dysfunctional cargos in cytoplasm, including unfolded proteins. Autophagy is involved in constructing the immunosuppressive microenvironment during tumor initiation and ...
Yuhe Lei +7 more
core +1 more source
Annexins: players of single cell wound healing and regeneration
Communicative & Integrative Biology, 2019 Cell life is defined by a thin 4 nm plasma membrane, which separates the interior of a cell from its environment. Thus, disruption of the plasma membrane poses a critical risk to cells, which requires immediate repair to avoid uncontrolled osmotic lysis ...
Swantje Christin Häger +1 more
doaj +1 more source
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
doaj +1 more source
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]
, 2013 Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Coombs, G.H. +8 more
core +1 more source
Annual Review of Cell and Developmental Biology, 2019 Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for autophagy in neurons, which catalyze the turnover of aged ...
Andrea K H, Stavoe, Erika L F, Holzbaur
openaire +3 more sources
, 2017 Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated with increasing mortality and morbidity. Therefore, there is a need to clearly define the COPD pathogenic mechanism and to explore effective therapies.
Hou, Hsin-Han;Cheng, Shih-Lung;Chung, Kuei-Pin;Kuo, Mark Yen-Ping;Yeh, Cheng-Chang;Chang, Bei-En;Lu, Hsuan-Hsuan;Wang, Hao-Chien;Yu, Chong-Jen +1 more
core +1 more source
Macrophage autophagy in atherosclerosis [PDF]
, 2013 Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Platt, A. +16 more
core +1 more source
BioMetals, 2014 Autophagy is a highly conserved degradative process through which cells overcome stressful conditions. Inasmuch as faulty autophagy has been associated with aging, neuronal degeneration disorders, diabetes, and fatty liver, autophagy is regarded as a potential therapeutic target. This review summarizes the present state of knowledge concerning the role
Juan P, Liuzzi +3 more
openaire +2 more sources
Cutting a fine figure : On the use of thin sections in electron microscopy to quantify autophagy
, 2013 Over the last few years, two guideline articles have been published with recommendations for assessing autophagy. These articles contained advice on quantification of autophagy by electron microscopy and proposed using thin slices for quantifying ...
Hacker, Christian, Lucocq, John Milton
core +1 more source