Results 41 to 50 of about 517,228 (307)

CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity [PDF]

, 2017
Background: Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation.
A Bhattacharya, AG Tzioufas, Annacarla Finucci, Antonina Minniti, Aroldo Rizzo, C Alessandri, C Li, C Vitali, C Vitali, CQ Nguyen, Cristiana Barbati, Cristiano Alessandri, D Geem, DJ Klionsky, DM Chisholm, E Astorri, Elena Ortona, Elisa Astorri, F Barone, F Ciccia, F Ciccia, F Ciccia, F Ciccia, F Sallusto, Fabrizio Conti, Francesco Ciccia, Giovanni Triolo, Giuliana Guggino, Guido Valesini, H Nakatogawa, HH Pua, HH Pua, HH Pua, I Tanida, LM Gerland, M Bombardieri, M Bombardieri, M Morgan-Bathke, M Morgan-Bathke, M Moriyama, M Pierdominici, Marina Pierdominici, Marta Vomero, Monica Pendolino, N Mizushima, N Schmitt, R Seror, Riccardo Alessandro, Roberta Priori, S Katsiougiannis, S Romao, Tania Colasanti, TC Adamson 3rd, W Jia, Walter Malorni, XJ Zhou, Y Seo, YZ Gong, Z Yang   +58 more
core   +3 more sources

Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley [PDF]

, 2018
Microspores are reprogrammed towards embryogenesis by stress. Many microspores die after this stress, limiting the efficiency of microspore embryogenesis. Autophagy is a degradation pathway that plays critical roles in stress response and cell death.
Berenguer, Eduardo, Bárány, Ivett, Crespo González, José Luis, Pérez Pérez, Yolanda, Risueño, M. Carmen   +4 more
core   +1 more source

Autophagy-Independent Functions of the Autophagy Machinery [PDF]

Cell, 2019
Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that
Galluzzi, Lorenzo, Green, Douglas R.
openaire   +3 more sources

Connexins : substrates and regulators of autophagy [PDF]

, 2016
Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert, D'hondt, Catheleyne, Decuypere, Jean-Paul, Iyyathurai, Jegan, Leybaert, Luc   +4 more
core   +1 more source

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Nature Communications, 2019
Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron   +8 more
doaj   +1 more source

Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]

, 2014
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Coombs, Graham H., Jones, Nathaniel G., Mottram, Jeremy C., Proto, William R.   +3 more
core   +3 more sources

Glycogen autophagy

Microscopy Research and Technique, 2004
AbstractGlycogen autophagy, which includes the sequestration and degradation of cell glycogen in the autophagic vacuoles, is a selective process under conditions of demand for the massive hepatic production of glucose, as in the postnatal period. It represents a link between autophagy and glycogen metabolism. The formation of autophagic vacuoles in the
Kotoulas, O. B., Kalamidas, S. A., Kondomerkos, D. J.   +2 more
openaire   +3 more sources

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +7 more sources

Emerging roles of TFE3 in metabolic regulation

Cell Death Discovery, 2023
TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic ...
Xingyu Li, Yongming Chen, Siqiao Gong, Huixia Chen, Huafeng Liu, Xiaoyu Li, Junfeng Hao   +6 more
doaj   +1 more source

MIR376A is a regulator of starvation-induced autophagy [PDF]

, 2013
Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Ali Kosar, B Ravikumar, B Teferedegne, BS Zhao, C le Sage, C Macedo, C Nakada, CJ Foley, D Gozuacik, D Nachmani, Deniz Gulfem Ozturk, Devrim Gozuacik, DJ Klionsky, E Chan, EJ Lee, F Wang, G Bjorkoy, G Korkmaz, G Russo, Gozde Korkmaz, H Seitz, H Siomi, HW Platta, I Tanida, J Hildebrand, J Winter, JS Lee, K Breving, K Duskova, KA Tekirdag, Kumsal Ayse Tekirdag, L Zehavi, LB Frankel, LB Frankel, LM Silva, M Kircher, MD Abramoff, N Mizushima, N Mizushima, N Mizushima, O Oral, Osman Ugur Sezerman, P Mestdagh, PM Voorhoeve, R Faraonio, R Scherz-Shouval, RC Russell, RC Wang, RL Skalsky, S Romao, S Sinha, Sebastien Pfeffer, T Wang, TG McDaneld, V Ambros, V Deretic, X Liu, X Zhang, Y Kabeya, Y Kawahara, Y Ohsumi   +60 more
core   +3 more sources