Results 101 to 110 of about 523,293 (245)
The autophagic degradation of cytosolic pools of peroxisomal proteins by a new selective pathway. [PDF]
, 2019 Damaged or redundant peroxisomes and their luminal cargoes are removed by pexophagy, a selective autophagy pathway. In yeasts, pexophagy depends mostly on the pexophagy receptors, such as Atg30 for Pichia pastoris and Atg36 for Saccharomyces cerevisiae ...
Farré, Jean-Claude +8 more
core +2 more sources
, 2017 The catabolic cellular processes collectively described as autophagy have been heavily implicated in the pathogenesis of Parkinsons disease by both genetic and cellular evidence. Drawing on the major advances in our understanding of Mendelian Parkinsons, as well as the identification of more common risk variants by genome-wide association studies ...
Lewis, P. A. +2 more
openaire +4 more sources
TURKISH JOURNAL OF BIOLOGY, 2014 Autophagy is an evolutionary conserved intracellular degradation and stress response mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic materials, including long-lived proteins, protein aggregates, and damaged organelles.
Karakaş, Hacer Ezgi +1 more
openaire +4 more sources
Bio-Protocol, 2018 In this protocol, we describe a method to monitor cell proliferation and death by live-cell imaging of propidium iodide (PI)-stained adherent mammalian cells. PI is widely used to assess cell death.
Paula Szalai, Nikolai Engedal
doaj +1 more source
Annals of MedicineObjective Minimal change disease (MCD) is a common nephrotic syndrome that is usually steroid-sensitive and has high relapse rate. The aim of this study was to investigate the relationship between time to clinical remission and recurrence after the ...
Xiuyue Ye +6 more
doaj +1 more source
LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. [PDF]
, 2019 During autophagy, actin filament networks move and remodel cellular membranes to form autophagosomes that enclose and metabolize cytoplasmic contents. Two actin regulators, WHAMM and JMY, participate in autophagosome formation, but the signals linking ...
Axe +40 more
core +2 more sources
From the regulatory mechanism of TFEB to its therapeutic implications
Cell Death DiscoveryTranscription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple
Huixia Chen +7 more
doaj +1 more source
Interplay between FGFR2b-induced autophagy and phagocytosis: role of PLCγ-mediated signalling [PDF]
, 2017 Signalling of the epithelial splicing variant of the fibroblast growth factor receptor 2 (FGFR2b) induces both autophagy and phagocytosis in human keratinocytes.
Belleudi, Francesca +4 more
core +1 more source
An ER-Localized SNARE Protein Is Exported in Specific COPII Vesicles for Autophagosome Biogenesis [PDF]
, 2016 The de novo formation of autophagosomes for the targeting of cytosolic material to the vacuole/lysosome is upregulated upon starvation. How autophagosomes acquire membranes remains still unclear. Here, we report that, in yeast, the endoplasmic reticulum (
Goder, Veit +3 more
core +1 more source
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1 [PDF]
, 2014 Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the ...
A Follenzi +46 more
core +3 more sources