Results 121 to 130 of about 373,644 (316)

Autophagy and disease [PDF]

Journal of Biological Chemistry, 2018
As outlined in the accompanying Minireviews, autophagy is a complicated and highly regulated process that delivers cellular material to lysosomes for degrading, recycling, and generating molecules that fuel cellular metabolism. Autophagy is important for normal cellular and organismal physiology, and both increased and decreased autophagy has been ...
openaire   +2 more sources

Autophagy in Age-Associated Neurodegeneration

, 2018
The elimination of abnormal and dysfunctional cellular constituents is an essential prerequisite for nerve cells to maintain their homeostasis and proper function.
Christina Ploumi, Athanasios Metaxakis, Nektarios Tavernarakis   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

From the regulatory mechanism of TFEB to its therapeutic implications

Cell Death Discovery
Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple
Huixia Chen, Siqiao Gong, Hongyong Zhang, Yongming Chen, Yonghan Liu, Junfeng Hao, Huafeng Liu, Xiaoyu Li   +7 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1

, 2014
Autophagy is a multistep process that involves the degradation and digestion of intracellular components by the lysosome. It has been proved that many core autophagy-related molecules participate in this event.
Liujing Qu (412279), Hu, Jia, He, Qihua, Zhenda Wang (412280), Li, Ge, Yaxin Lou (686919), Dalong Ma (412281), Qu, Liujing, Yingyu Chen (161120), Lou, Yaxin, Quansheng Song (686920), Ma, Dalong, Jia Hu (77170), Song, Quansheng, Qihua He (644192), Chen, Yingyu, Wang, Zhenda, Ge Li (65539)   +17 more
core   +1 more source

Acidic sphingomyelinase interactions with lysosomal membranes and cation amphiphilic drugs: A molecular dynamics investigation

Computational and Structural Biotechnology Journal
Lysosomes are pivotal in cellular functions and disease, influencing cancer progression and therapy resistance with Acid Sphingomyelinase (ASM) governing their membrane integrity.
Simone Scrima, Matteo Lambrughi, Lorenzo Favaro, Kenji Maeda, Marja Jäättelä, Elena Papaleo   +5 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling

, 2016
MARCH2 (membrane-associated RING-CH protein 2), an E3 ubiquitin ligase, is mainly associated with the vesicle trafficking. In the present study, for the first time, we demonstrated that MARCH2 negatively regulates autophagy.
Liujing Qu (412279), Lin, Xin, Xin Lin (149944), Dan Xia (1775776), He, Qihua, Li, Ge, Yaxin Lou (686919), Dalong Ma (412281), Qu, Liujing, Yingyu Chen (161120), Xu, Chentong, Lou, Yaxin, Hongdu, Beiqi, Chentong Xu (2832008), Beiqi Hongdu (2832011), Ma, Dalong, Qihua He (644192), Xia, Dan, Chen, Yingyu, Ge Li (65539)   +19 more
core   +1 more source

Mitochondrial metabolism and targeted treatment strategies in ischemic-induced acute kidney injury

Cell Death Discovery
Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The kidney is susceptible to IRI under several clinical conditions, including hypotension, sepsis, and surgical procedures, such as partial nephrectomy and kidney ...
Yongming Chen, Zixian Li, Hongyong Zhang, Huixia Chen, Junfeng Hao, Huafeng Liu, Xiaoyu Li   +6 more
doaj   +1 more source