Results 121 to 130 of about 401,976 (308)

The role of autophagy in intestinal T cell homeostasis [PDF]

, 2015
A polymorphism in the essential autophagy gene ATG16L1 is associated with susceptibility to inflammatory bowel disease. However, the role of autophagy in maintenance of intestinal immune homeostasis remains unclear.
Kabat, Agnieszka M, Agnieszka M Kabat
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Characterization and Investigation of the Toxicity, Genotoxicity, Antioxidant, and Radical Scavenging Activity of Highly Fluorescent Nitrogen-Doped Graphene Quantum Dots (NGQDs) [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Nitrogen-Doped Graphene Quantum Dots (NGQDs) have recently been used effectively in drug delivery. Our study aimed to characterize NGQDs and investigate their toxicity and genotoxicity using the Brine Shrimp lethality test (BSLT), Allium cepa L assay ...
Mehdi Ghavamizadeh, Azam Habibi, Sanaz Dastghaib, Mazaher Ahmadi, Pooneh Mokarram   +4 more
doaj   +1 more source

Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage

, 2012
Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy. Furthermore, our results revealed that curcumin causes some novel cellular mechanisms that promote autophagy as a ...
An, Yu, Li, Xue-Jun, Tie, Lu, Xu, Yan, Xiao, Yuan, Pan, Xue-Yang, Han, Jing, Pan, Yan   +7 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Role of Selective Autophagy in Spermatogenesis and Male Fertility

, 2020
Autophagy is a “self-eating” process that engulfs cellular contents for their subsequent digestion in lysosomes to engage the metabolic need in response to starvation or environmental insults.
Chunyu Lv, Xiaoli Wang, Shuiqiao Yuan, Ying Guo   +3 more
core   +1 more source

From the regulatory mechanism of TFEB to its therapeutic implications

Cell Death Discovery
Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple
Huixia Chen, Siqiao Gong, Hongyong Zhang, Yongming Chen, Yonghan Liu, Junfeng Hao, Huafeng Liu, Xiaoyu Li   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Acidic sphingomyelinase interactions with lysosomal membranes and cation amphiphilic drugs: A molecular dynamics investigation

Computational and Structural Biotechnology Journal
Lysosomes are pivotal in cellular functions and disease, influencing cancer progression and therapy resistance with Acid Sphingomyelinase (ASM) governing their membrane integrity.
Simone Scrima, Matteo Lambrughi, Lorenzo Favaro, Kenji Maeda, Marja Jäättelä, Elena Papaleo   +5 more
doaj   +1 more source