Results 111 to 120 of about 286,383 (199)

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Induction of autophagy in one-cell stage somatic cell nuclear transfer embryos improves preimplantation embryonic development in goat species. [PDF]

PLoS One
Mahvash N, Moradi-Hajidavaloo R, Jafarpour F, Hajian M, Rahimi M, Sanei Ata-Abadi N, Sadeghi M, Nasr-Esfahani MH.   +7 more
europepmc   +1 more source

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Advanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu   +8 more
wiley   +1 more source

Autophagy is induced during cell death by incompatibility and is essential for differentiation in the filamentous fungus Podospora anserina [PDF]

, 2003
Bérangère Pinan‐Lucarré, Mathieu Paoletti, Karine Dementhon, Bénédicte Coulary‐Salin, Corinne Clavé   +4 more
openalex   +1 more source

Rice stripe mosaic virus M protein antagonizes G-protein-induced antiviral autophagy in insect vectors. [PDF]

PLoS Pathog
Zhang R, Wang T, Cheng Y, Qiu J, Jia D, Chen H, Wei T, Zhang XF.   +7 more
europepmc   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

The Ras/cAMP-dependent Protein Kinase Signaling Pathway Regulates an Early Step of the Autophagy Process in Saccharomyces cerevisiae [PDF]

, 2004
Yelena V. Budovskaya, Joseph S. Stephan, Fulvio Reggiori, Daniel J. Klionsky, Paul K. Herman   +4 more
openalex   +1 more source

Nanomaterial-Based Autophagy Modulation: Multiple Weapons to Inflame Immune Systems and the Tumor Microenvironment. [PDF]

Biomater Res
Jiang M, Zhang X, Cui Z, Li M, Qiang H, Ji K, Li M, Yuan XX, Wen B, Xue Q, Gao J, Lu Z, Wu Y.   +12 more
europepmc   +1 more source

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

Coronavirus Replication Complex Formation Utilizes Components of Cellular Autophagy [PDF]

, 2004
Erik Prentice, W. Gray Jerome, Tamotsu Yoshimori, Noboru Mizushima, Mark R. Denison   +4 more
openalex   +1 more source