Results 121 to 130 of about 687,627 (397)

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Autophagy, 2020
Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates.
Changfeng Li, Ying Zhang, Jiao Liu, R. Kang, D. Klionsky, D. Tang   +5 more
semanticscholar   +1 more source

Autophagie [PDF]

Biologie in unserer Zeit, 2012
AbstractUnser Titelbild zeigt Gehirnzellen (Astrozyten) in Kultur. Ihr Cytoskelett ist blau gefärbt. In den Zellen wurden durch Hemmung des roteasomalen Proteinabbaus große und kleine Proteinablagerungen (rot) erzeugt. Diese Proteinaggregate können durch Autophagie wieder entfernt werden.
openaire   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]

, 2016
Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C, CARDINALI, CLAUDIO, GISMONDI, Angela, MORELLI, MARIA BEATRICE, Nabissi, M, Santoni, G., Santoni, M   +6 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

WIPI-Mediated Autophagy and Longevity

Cells, 2015
Autophagy is a lysosomal degradation process for cytoplasmic components, including organelles, membranes, and proteins, and critically secures eukaryotic cellular homeostasis and survival.
Mona Grimmel, Charlotte Backhaus, Tassula Proikas-Cezanne   +2 more
doaj   +1 more source

BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. [PDF]

, 2016
The proteasome inhibitor MLN9708 is an orally administered drug that is hydrolyzed into its active form, MLN2238 (ixazomib). Compared with Bortezomib, MLN2238 has a shorter proteasome dissociation half-life and a lower incidence and severity of ...
Barkhouse, Darryll, Li, Guichao, Lu, Bo, Wan, Juefeng, Xiao, Sheng, Yang, Lifeng, Zhang, Zhen, Zhu, Ji   +7 more
core   +2 more sources

Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Supported by Its Specific Subcellular Localization [PDF]

, 2020
Francisco J. Sala de Oyanguren, Nathan E. Rainey, Aoula Moustapha, Ana Šarić, Franck Sureau, José‐Enrique O’Connor, Patrice X. Petit   +6 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Exploring the role of gut microbiota modulation in the long-term therapeutic benefits of early MSC transplantation in MRL/lpr mice

Cellular & Molecular Biology Letters
Background Systemic lupus erythematosus (SLE), influenced by gut microbiota dysbiosis, is characterized by autoimmune and inflammatory responses. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation is an effective and safe ...
Quanren Pan, Fengbiao Guo, Jiaxuan Chen, Haimin Huang, Yanyan Huang, Shuzhen Liao, Zengzhi Xiao, Xi Wang, Liuyong You, Lawei Yang, Xuemei Huang, Haiyan Xiao, Hua-Feng Liu, Qingjun Pan   +13 more
doaj   +1 more source