Results 301 to 310 of about 687,627 (397)

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source

Evaluating the Therapeutic Potential of MRT68921 and Afatinib in Three-Dimensional Models of Epithelial Ovarian Cancer. [PDF]

Cancers (Basel)
Johnston TPA, Webb JD, Borrelli MJ, Tomas EJ, Pucchio ÁC, Valdés YR, Shepherd TG.   +6 more
europepmc   +1 more source

Molecular definitions of autophagy and related processes

EMBO Journal, 2017
L. Galluzzi, E. Baehrecke, A. Ballabio, P. Boya, J. M. Bravo-San Pedro, F. Cecconi, A. Choi, C. Chu, P. Codogno, M. Colombo, A. Cuervo, Jayanta Debnath, V. Deretic, I. Dikič, E. Eskelinen, G. Fimia, S. Fulda, D. Gewirtz, D. Green, M. Hansen, J. Harper, M. Jäättelä, T. Johansen, G. Juhász, Alec C. Kimmelman, C. Kraft, N. Ktistakis, Sharad Kumar, B. Levine, C. López-Otín, F. Madeo, Sascha Martens, Jennifer Martinez, A. Meléndez, N. Mizushima, C. Münz, Leon O. Murphy, J. Penninger, M. Piacentini, F. Reggiori, D. Rubinsztein, K. Ryan, L. Santambrogio, L. Scorrano, A. Simon, H. Simon, A. Simonsen, Nektarios Tavernarakis, S. Tooze, T. Yoshimori, Junying Yuan, Zhenyu Yue, Q. Zhong, G. Kroemer   +53 more
semanticscholar   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Regulatory mechanism of O-linked N-acetylglucosamine protein modification on autophagy in cancer. [PDF]

Clin Transl Med
Li Y, Gao L, Li S, Zheng J, Zhi K, Ren W.   +5 more
europepmc   +1 more source

A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy [PDF]

, 2018
Allavena, Giulia, Debellis, Doriana, Grimaldi, Benedetto, Joshi, Chetanchandra S, Marotta, Roberto, Mysorekar, Indira U   +5 more
core   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Autophagy.

Acta medica Indonesiana, 2008
openaire   +3 more sources

Autophagy, Cellular Senescence and Oxidative Stress in Ageing and Age-Related Diseases. [PDF]

Int J Mol Sci
Trachana V.
europepmc   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source