Results 281 to 290 of about 401,976 (308)
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Molecular Immunology, 2017
Autophagy is a ubiquitous cellular mechanism for the targeted lysosomal degradation of various cytosolic constituents, from proteins to organelles. As an essential homeostatic mechanism, autophagy is upregulated in response to numerous environmental and pharmacological stimuli, including starvation, where it facilitates the recycling of essential amino
James, Harris +5 more
openaire +2 more sources
Autophagy is a ubiquitous cellular mechanism for the targeted lysosomal degradation of various cytosolic constituents, from proteins to organelles. As an essential homeostatic mechanism, autophagy is upregulated in response to numerous environmental and pharmacological stimuli, including starvation, where it facilitates the recycling of essential amino
James, Harris +5 more
openaire +2 more sources
Current Atherosclerosis Reports, 2008
Autophagy is a catabolic pathway for bulk destruction of long-lived proteins and organelles via lysosomes. Basal autophagy represents a reparative, life-sustaining process, but unrestrained autophagic activity promotes cell death. A growing body of evidence suggests that autophagy occurs in advanced atherosclerotic plaques. Vascular smooth muscle cells,
Martinet, Wim, De Meyer, Guido R.Y.
openaire +3 more sources
Autophagy is a catabolic pathway for bulk destruction of long-lived proteins and organelles via lysosomes. Basal autophagy represents a reparative, life-sustaining process, but unrestrained autophagic activity promotes cell death. A growing body of evidence suggests that autophagy occurs in advanced atherosclerotic plaques. Vascular smooth muscle cells,
Martinet, Wim, De Meyer, Guido R.Y.
openaire +3 more sources
2014
Osteosarcoma (OS) metastatic disease is resistant to conventional chemotherapy. Tumor resistance to chemotherapy has been one of the major areas of concern to clinicians and the topic of many laboratory investigators. Evaluation of mechanisms implicated in OS lung metastasis resistance to chemotherapy has been the focus of some of our most recent work.
Janice Santiago, O'Farrill +1 more
openaire +2 more sources
Osteosarcoma (OS) metastatic disease is resistant to conventional chemotherapy. Tumor resistance to chemotherapy has been one of the major areas of concern to clinicians and the topic of many laboratory investigators. Evaluation of mechanisms implicated in OS lung metastasis resistance to chemotherapy has been the focus of some of our most recent work.
Janice Santiago, O'Farrill +1 more
openaire +2 more sources
2010
Autophagy is a cellular quality control process by which cytoplasmic constituents including proteins, protein aggregates, organelles, and invading pathogens can be delivered to lysosomes for degradation. Autophagy is activated in response to changes in the internal status of the cell and/or changes in the extracellular environment.
Dalibor, Mijaljica +2 more
openaire +2 more sources
Autophagy is a cellular quality control process by which cytoplasmic constituents including proteins, protein aggregates, organelles, and invading pathogens can be delivered to lysosomes for degradation. Autophagy is activated in response to changes in the internal status of the cell and/or changes in the extracellular environment.
Dalibor, Mijaljica +2 more
openaire +2 more sources
Autophagy as a promoter of longevity: insights from model organisms
Nature Reviews Molecular Cell Biology, 2018David Rubinsztein +2 more
exaly
Mechanistic insights into selective autophagy pathways: lessons from yeast
Nature Reviews Molecular Cell Biology, 2016Jean-Claude Farré, Suresh Subramani
exaly
Mechanism and medical implications of mammalian autophagy
Nature Reviews Molecular Cell Biology, 2018Ivan Dikić, Zvulun Elazar
exaly
Bacteria–autophagy interplay: a battle for survival
Nature Reviews Microbiology, 2014John Brumell
exaly