Results 281 to 290 of about 373,644 (316)
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2020
Epilepsy is a long-term neurological disease characterized by convulsions that can be recurrent. It is mainly caused by an imbalance between excitation and inhibition in the central nervous system. Currently, the pathogenesis is still unclear, although it may be related to changes in ion channels, neurotransmitters and glial cells.
Meihong, Lv, Quanhong, Ma
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Epilepsy is a long-term neurological disease characterized by convulsions that can be recurrent. It is mainly caused by an imbalance between excitation and inhibition in the central nervous system. Currently, the pathogenesis is still unclear, although it may be related to changes in ion channels, neurotransmitters and glial cells.
Meihong, Lv, Quanhong, Ma
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Assays for Autophagy II: Mitochondrial Autophagy
2014Autophagy is a bulk degradation process of cytosolic proteins and organelles through the lysosomal/vacuolar machinery. Mitophagy is a type of autophagy that selectively degrades mitochondria. Recent studies have revealed that mitophagy plays an important role in cellular mitochondrial quality control.
Tomotake, Kanki, Koji, Okamoto
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Annual Review of Biophysics, 2015
The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome.
Nobuo N, Noda, Fuyuhiko, Inagaki
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The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome.
Nobuo N, Noda, Fuyuhiko, Inagaki
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2020
Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy.
Grace, Nehme, Nancy, Gordon
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Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy.
Grace, Nehme, Nancy, Gordon
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2020
Hypertension is one of the most common cardiovascular diseases. Sympathetic hyperactivity and renin-angiotensin-aldosterone system activation cause changes in cardiovascular structure and function. Autophagy plays an important role in cellular waste removal and structural reconstruction.
Jie, Du, Congcong, Zhang, Wei, Zhao
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Hypertension is one of the most common cardiovascular diseases. Sympathetic hyperactivity and renin-angiotensin-aldosterone system activation cause changes in cardiovascular structure and function. Autophagy plays an important role in cellular waste removal and structural reconstruction.
Jie, Du, Congcong, Zhang, Wei, Zhao
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2021
Biomarkers (short for biological markers) are biological measures of a biological state. Autophagy biomarkers play an important role as an indicator of autophagy during normal physiological processes, pathogenic processes or pharmacological responses to drugs.
Fang, Lin, Yu-Ting, Zhu, Zheng-Hong, Qin
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Biomarkers (short for biological markers) are biological measures of a biological state. Autophagy biomarkers play an important role as an indicator of autophagy during normal physiological processes, pathogenic processes or pharmacological responses to drugs.
Fang, Lin, Yu-Ting, Zhu, Zheng-Hong, Qin
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Connective Tissue Research, 2016
Osteoarthritis is characterized by continuous degeneration of articular cartilage resulting in disability. The death of chondrocytes and the loss of the extracellular matrix are the central peculiarities in cartilage degeneration during osteoarthritis pathogenesis. Autophagy is an essential cellular homeostasis mechanism whereby cellular organelles and
Hyelin, Jeon, Gun-Il, Im
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Osteoarthritis is characterized by continuous degeneration of articular cartilage resulting in disability. The death of chondrocytes and the loss of the extracellular matrix are the central peculiarities in cartilage degeneration during osteoarthritis pathogenesis. Autophagy is an essential cellular homeostasis mechanism whereby cellular organelles and
Hyelin, Jeon, Gun-Il, Im
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Autophagy is a process involved in the proteolytic degradation of cellular macromolecules in lysosomes, which requires the activity of proteases, enzymes that hydrolyse peptide bonds and play a critical role in the initiation and execution of autophagy. Importantly, proteases also inhibit autophagy in certain cases.
Kaminskyy, Vitaliy, Zhivotovsky, Boris
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Autophagy is a process involved in the proteolytic degradation of cellular macromolecules in lysosomes, which requires the activity of proteases, enzymes that hydrolyse peptide bonds and play a critical role in the initiation and execution of autophagy. Importantly, proteases also inhibit autophagy in certain cases.
Kaminskyy, Vitaliy, Zhivotovsky, Boris
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Cellular and Molecular Life Sciences, 2015
Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular and molecular mechanisms underlying this process are highly complex and involve multiple proteins, including the kinases ULK1 and Vps34. The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment.
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Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular and molecular mechanisms underlying this process are highly complex and involve multiple proteins, including the kinases ULK1 and Vps34. The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment.
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2020
Leukemia is a malignant clonal disease that originates from hematopoietic stem cells. As in-depth research examines the molecular biology and immunology of the hematopoietic system, leukemia treatment has evolved from a single cytotoxic drug to treatments that inducing differentiation and apoptosis.
Zhong, Zheng +4 more
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Leukemia is a malignant clonal disease that originates from hematopoietic stem cells. As in-depth research examines the molecular biology and immunology of the hematopoietic system, leukemia treatment has evolved from a single cytotoxic drug to treatments that inducing differentiation and apoptosis.
Zhong, Zheng +4 more
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