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Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone. [PDF]

open access: yesBone Rep
James A   +8 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

open access: yes
Advanced Science, EarlyView.
Miao Yu   +7 more
wiley   +1 more source

Autophagy and autophagy-related pathways in cancer

open access: yesNature Reviews Molecular Cell Biology, 2023
Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and recycling. A myriad of studies demonstrate important protective roles for autophagy against disease.
Noor Gammoh   +2 more
exaly   +5 more sources
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Autophagy

1996
Autophagy or autophagocytosis are terms given to a membrane-mediated process in eukaryotic cells in which portions of cytoplasm are sequestered within vacuoles and degraded by acid hydrolases that are acquired by fusion with lysosomes. Although vacuoles of this type may be formed under pathologic conditions, autophagy is fundamentally a physiologic ...
MORTIMORE G. E.   +3 more
openaire   +3 more sources

Autophagy in Huntington disease and huntingtin in autophagy

Trends in Neurosciences, 2015
Autophagy is an important biological process that is essential for the removal of damaged organelles and toxic or aggregated proteins by delivering them to the lysosome for degradation. Consequently, autophagy has become a primary target for the treatment of neurodegenerative diseases that involve aggregating proteins.
Dale D O, Martin   +3 more
openaire   +2 more sources

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