Results 271 to 280 of about 401,976 (308)
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Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy
Cell Biochemistry and Function, 2019The ataxia‐telangiectasia mutated (ATM) protein kinase is best known for its critical nuclear roles in the DNA damage response (DDR), cell cycle checkpoints, and the maintenance of gene stability. In this review, we highlight the multifaceted cytoplasmic functions of ATM in autophagy.
Nan Liang +3 more
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Annals of the New York Academy of Sciences, 2006
Abstract: Autophagy is a major intracellular pathway for the degradation and recycling of long‐lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms.
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Abstract: Autophagy is a major intracellular pathway for the degradation and recycling of long‐lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms.
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Assays for Autophagy II: Mitochondrial Autophagy
2014Autophagy is a bulk degradation process of cytosolic proteins and organelles through the lysosomal/vacuolar machinery. Mitophagy is a type of autophagy that selectively degrades mitochondria. Recent studies have revealed that mitophagy plays an important role in cellular mitochondrial quality control.
Tomotake, Kanki, Koji, Okamoto
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Annual Review of Biophysics, 2015
The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome.
Nobuo N, Noda, Fuyuhiko, Inagaki
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The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome.
Nobuo N, Noda, Fuyuhiko, Inagaki
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2020
Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy.
Grace, Nehme, Nancy, Gordon
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Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy.
Grace, Nehme, Nancy, Gordon
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2020
Hypertension is one of the most common cardiovascular diseases. Sympathetic hyperactivity and renin-angiotensin-aldosterone system activation cause changes in cardiovascular structure and function. Autophagy plays an important role in cellular waste removal and structural reconstruction.
Jie, Du, Congcong, Zhang, Wei, Zhao
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Hypertension is one of the most common cardiovascular diseases. Sympathetic hyperactivity and renin-angiotensin-aldosterone system activation cause changes in cardiovascular structure and function. Autophagy plays an important role in cellular waste removal and structural reconstruction.
Jie, Du, Congcong, Zhang, Wei, Zhao
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Connective Tissue Research, 2016
Osteoarthritis is characterized by continuous degeneration of articular cartilage resulting in disability. The death of chondrocytes and the loss of the extracellular matrix are the central peculiarities in cartilage degeneration during osteoarthritis pathogenesis. Autophagy is an essential cellular homeostasis mechanism whereby cellular organelles and
Hyelin, Jeon, Gun-Il, Im
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Osteoarthritis is characterized by continuous degeneration of articular cartilage resulting in disability. The death of chondrocytes and the loss of the extracellular matrix are the central peculiarities in cartilage degeneration during osteoarthritis pathogenesis. Autophagy is an essential cellular homeostasis mechanism whereby cellular organelles and
Hyelin, Jeon, Gun-Il, Im
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Current Protocols in Cytometry, 2014
AbstractAutophagy is a membrane‐trafficking pathway activated to deliver cytosolic material for degradation to lysosomes through a novel membrane compartment, the autophagosome. Fluorescence microscopy is the most common method used to visualize proteins inside cells, and it is widely used in the autophagy field.
Eleftherios, Karanasios +3 more
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AbstractAutophagy is a membrane‐trafficking pathway activated to deliver cytosolic material for degradation to lysosomes through a novel membrane compartment, the autophagosome. Fluorescence microscopy is the most common method used to visualize proteins inside cells, and it is widely used in the autophagy field.
Eleftherios, Karanasios +3 more
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Cellular and Molecular Life Sciences, 2015
Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular and molecular mechanisms underlying this process are highly complex and involve multiple proteins, including the kinases ULK1 and Vps34. The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment.
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Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular and molecular mechanisms underlying this process are highly complex and involve multiple proteins, including the kinases ULK1 and Vps34. The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment.
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Annual Review of Immunology, 2018
The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from
Yu, Matsuzawa-Ishimoto +2 more
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The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from
Yu, Matsuzawa-Ishimoto +2 more
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