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Autophagy activation by urolithin-a derivative UA-36 mitigates Friedreich's ataxia pathologies induced by frataxin deficiency. [PDF]
Mol BiomedGong Q +10 more
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Correction: Li et al. The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6468. [PDF]
Int J Mol SciLi Y, Yan W, Qin Y, Zhang L, Xiao S.
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Autophagy and autophagy-related pathways in cancer
Nature Reviews Molecular Cell Biology, 2023 Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and recycling. A myriad of studies demonstrate important protective roles for autophagy against disease.
Jayanta Debnath +2 more
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Autophagy in Huntington disease and huntingtin in autophagy
Trends in Neurosciences, 2015Autophagy is an important biological process that is essential for the removal of damaged organelles and toxic or aggregated proteins by delivering them to the lysosome for degradation. Consequently, autophagy has become a primary target for the treatment of neurodegenerative diseases that involve aggregating proteins.
Dale D O, Martin +3 more
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1996
Autophagy or autophagocytosis are terms given to a membrane-mediated process in eukaryotic cells in which portions of cytoplasm are sequestered within vacuoles and degraded by acid hydrolases that are acquired by fusion with lysosomes. Although vacuoles of this type may be formed under pathologic conditions, autophagy is fundamentally a physiologic ...
MORTIMORE G. E. +3 more
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Autophagy or autophagocytosis are terms given to a membrane-mediated process in eukaryotic cells in which portions of cytoplasm are sequestered within vacuoles and degraded by acid hydrolases that are acquired by fusion with lysosomes. Although vacuoles of this type may be formed under pathologic conditions, autophagy is fundamentally a physiologic ...
MORTIMORE G. E. +3 more
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Annals of the New York Academy of Sciences, 2006
Abstract: Autophagy is a major intracellular pathway for the degradation and recycling of long‐lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms.
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Abstract: Autophagy is a major intracellular pathway for the degradation and recycling of long‐lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms.
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Autophagy and neurodegeneration
Current Neurology and Neuroscience Reports, 2007All cellular components are subjected to continuous surveillance by intracellular quality control systems. The major players involved in this quality control are molecular chaperones, which detect the abnormal components, and proteases, which eliminate them from the cell.
Annamaria, Ventruti, Ana Maria, Cuervo
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